Gene Symbol | NEURL2 |
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Entrez Gene | 140825 |
Alt Symbol | C20orf163, OZZ, OZZ-E3 |
Species | Human |
Gene Type | protein-coding |
Description | neuralized E3 ubiquitin protein ligase 2 |
Other Description | neuralized homolog 2|neuralized-like protein 2 |
Swissprots | Q3KR34 Q9BR09 |
Accessions | EAW75790 Q9BR09 AJ295985 CAC82498 AK054821 BAB70810 AW298115 AW515245 BC074737 AAH74737 BC105935 AAI05936 BC107485 AAI07486 HY058356 NM_001278535 NP_001265464 NM_080749 NP_542787 |
Function | Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed specifically in skeletal and cardiac muscles. {ECO:0000269|PubMed:14960280}. |
Neuralized-2 CRISPR/Cas9 KO Plasmid (h) - sc-407560 from Santa Cruz Biotechnology
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Neuralized-2 HDR Plasmid (h) - sc-407560-HDR from Santa Cruz Biotechnology
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Neuralized-2 Double Nickase Plasmid (h) - sc-407560-NIC from Santa Cruz Biotechnology
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Neuralized-2 Double Nickase Plasmid (h2) - sc-407560-NIC-2 from Santa Cruz Biotechnology
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Neuralized-2 CRISPR Activation Plasmid (h) - sc-407560-ACT from Santa Cruz Biotechnology
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Neuralized-2 CRISPR Activation Plasmid (h2) - sc-407560-ACT-2 from Santa Cruz Biotechnology
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Neuralized-2 Lentiviral Activation Particles (h) - sc-407560-LAC from Santa Cruz Biotechnology
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Neuralized-2 Lentiviral Activation Particles (h2) - sc-407560-LAC-2 from Santa Cruz Biotechnology
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Neuralized-2 siRNA (h) - sc-75905 from Santa Cruz Biotechnology
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Neuralized-2 shRNA Plasmid (h) - sc-75905-SH from Santa Cruz Biotechnology
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Neuralized-2 shRNA (h) Lentiviral Particles - sc-75905-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU014071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15221 from Sigma-Aldrich
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NEURL2 siRNA (Human) - CRJ5327 from Cohesion Biosciences
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shRNA set against Human NEURL2 (NM_080749.2) - SHH351520 from Creative biogene
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Human NEURL2 siRNA - orb275828 from Biorbyt
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NEURL2 shRNA Plasmid (Human) - CHJ5327 from Cohesion Biosciences
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NEURL2 miRNA 3'UTR clone - MiUTR1H-06726 from Creative biogene
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