PRMT6

Gene Symbol	PRMT6
Entrez Gene	55170
Alt Symbol	HRMT1L6
Species	Human
Gene Type	protein-coding
Description	protein arginine methyltransferase 6
Other Description	HMT1 hnRNP methyltransferase-like 6|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6|histone-arginine N-methyltransferase PRMT6|protein arginine N-methyltransferase 6
Swissprots	Q5T5Y5 Q6DKI4 Q96LA8 Q9NVR8 B4DID8 A3KME1
Accessions	EAW51248 Q96LA8 AI754232 AK001421 BAA91681 AK226009 AK295541 BAG58450 AK297898 BAG60218 AY043278 AAK85733 BC002729 AAH02729 BC013866 BC063446 AAH63446 BC073866 AAH73866 DA073209 NM_018137 NP_060607
Function	Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enha
Subcellular Location	Nucleus {ECO:0000269|PubMed:11724789}.
Tissue Specificity	Highly expressed in kidney and testis. {ECO:0000269|PubMed:11724789}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRMT6-Over-expression-Lysate - LY12157a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PRMT6 293T Cell Transient Overexpression Lysate(Denatured) - H00055170-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PRMT6 overexpression lysate - LY413290 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PRMT6 overexpression lysate - LY432201 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PRMT6 293 Cell Lysate - 406438 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PRMT6 Overexpression Lysate (Denatured) - H00055170-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

PRMT6 Overexpression Lysate (Native) - NBL1-14796 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PRMT6 Over-expression Lysate Product - GWB-9E1BB2 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human PRMT6 / HRMT1L6 HEK293 Cell Lysate (WB positive control) - 11313-H18HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human PRMT6 Human Cells Transfected Lysate (positive control) (denatured) - orb173368 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

PRMT6 Overexpression Lysate (Native) - NBP2-10229 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human PRMT6 Knockdown Stable Cell Line - CSC-DC012429 from Creative biogene Category Cell Line Species Human

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