| Gene Symbol |
PRMT6
|
| Entrez Gene |
55170
|
| Alt Symbol |
HRMT1L6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein arginine methyltransferase 6
|
| Other Description |
HMT1 hnRNP methyltransferase-like 6|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6|histone-arginine N-methyltransferase PRMT6|protein arginine N-methyltransferase 6
|
| Swissprots |
Q5T5Y5 Q6DKI4 Q96LA8 Q9NVR8 B4DID8 A3KME1
|
| Accessions |
EAW51248 Q96LA8 AI754232 AK001421 BAA91681 AK226009 AK295541 BAG58450 AK297898 BAG60218 AY043278 AAK85733 BC002729 AAH02729 BC013866 BC063446 AAH63446 BC073866 AAH73866 DA073209 NM_018137 NP_060607
|
| Function |
Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enha
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11724789}.
|
| Tissue Specificity |
Highly expressed in kidney and testis. {ECO:0000269|PubMed:11724789}.
|