PRMT6

Gene Symbol PRMT6
Entrez Gene 55170
Alt Symbol HRMT1L6
Species Human
Gene Type protein-coding
Description protein arginine methyltransferase 6
Other Description HMT1 hnRNP methyltransferase-like 6|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6|histone-arginine N-methyltransferase PRMT6|protein arginine N-methyltransferase 6
Swissprots Q5T5Y5 Q6DKI4 Q96LA8 Q9NVR8 B4DID8 A3KME1
Accessions EAW51248 Q96LA8 AI754232 AK001421 BAA91681 AK226009 AK295541 BAG58450 AK297898 BAG60218 AY043278 AAK85733 BC002729 AAH02729 BC013866 BC063446 AAH63446 BC073866 AAH73866 DA073209 NM_018137 NP_060607
Function Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enha
Subcellular Location Nucleus {ECO:0000269|PubMed:11724789}.
Tissue Specificity Highly expressed in kidney and testis. {ECO:0000269|PubMed:11724789}.

Active human PRMT6 full length protein - ab196434 from Abcam

Category Protein
Prices $1,250.00
Sizes 20 µg
Source E. coli
Species Human
SDS-PAGE analysis of 3 μg of ab196434 on a 10% SDS-PAGE gel stained with Coomassie.

Human PRMT6 full length protein - ab153394 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153394 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human PRMT6 protein fragment - ab153395 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153395 on a 12.5% SDS-PAGE stained with Coomassie Blue.

PRMT6 Antibody Blocking Peptide - LS-E44 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PRMT6 Antibody Blocking Peptide - LS-E14625 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PRMT6 Antibody Blocking Peptide - LS-E14624 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PRMT6 Antibody Blocking Peptide - LS-E27912 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human PRMT6 Protein - H00055170-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human PRMT6 Protein - H00055170-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

PRMT6 Peptide - P0149 from Novus Biologicals

Category Peptide
Species Human

PRMT6-Antibody-N-term-Blocking-Peptide - BP1009a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Human PRMT 6 protein - orb83616 from Biorbyt

Category Protein
Prices $357.00, $612.00
Sizes 20 μg, 50 μg
Source Human
Species Human
SDS-PAGE analysis of Human PRMT6 Flag His tag protein

PRMT6 Blocking Peptide - 33R-3040 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

PRMT6 Blocking Peptide - 33R-10623 from Fitzgerald

Category Peptide
Prices $115.00
Sizes 50 µg

PRMT6 Peptide - AC21-2685-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

PRMT6 / HRMT1L6 - H00055170-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

PRMT6 / HRMT1L6 - H00055170-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

PRMT6 / HRMT1L6 - H00055170-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

PRMT6 / HRMT1L6 - H00055170-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

PRMT6 Peptide - 43-055P from ProSci

Category Peptide
Species Human

PRMT6 fusion protein - Ag7592 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

PRMT6 fusion protein - ag7934 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant PRMT6 protein - 31394 from ActiveMotif

Category Protein
Prices $425.00
Sizes 20 µg
Source Baculovirus
Species Human
Recombinant PRMT6 protein gel. PRMT6 protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue.

Recombinant Human Protein Arginine Methyltransferase 6 - PRMT6-453H from Creative Biomart

Category Protein
Source E.coli

Recombinant Human Protein Arginine Methyltransferase 6, Flag-tagged - PRMT6-653H from Creative Biomart

Category Protein
Source Human Cells.
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