Gene Symbol | PRMT6 |
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Entrez Gene | 55170 |
Alt Symbol | HRMT1L6 |
Species | Human |
Gene Type | protein-coding |
Description | protein arginine methyltransferase 6 |
Other Description | HMT1 hnRNP methyltransferase-like 6|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6|histone-arginine N-methyltransferase PRMT6|protein arginine N-methyltransferase 6 |
Swissprots | Q5T5Y5 Q6DKI4 Q96LA8 Q9NVR8 B4DID8 A3KME1 |
Accessions | EAW51248 Q96LA8 AI754232 AK001421 BAA91681 AK226009 AK295541 BAG58450 AK297898 BAG60218 AY043278 AAK85733 BC002729 AAH02729 BC013866 BC063446 AAH63446 BC073866 AAH73866 DA073209 NM_018137 NP_060607 |
Function | Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enha |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11724789}. |
Tissue Specificity | Highly expressed in kidney and testis. {ECO:0000269|PubMed:11724789}. |
Active human PRMT6 full length protein - ab196434 from Abcam
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Human PRMT6 full length protein - ab153394 from Abcam
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Human PRMT6 protein fragment - ab153395 from Abcam
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PRMT6 Antibody Blocking Peptide - LS-E44 from LifeSpan Bioscience
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PRMT6 Antibody Blocking Peptide - LS-E14625 from LifeSpan Bioscience
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PRMT6 Antibody Blocking Peptide - LS-E14624 from LifeSpan Bioscience
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PRMT6 Antibody Blocking Peptide - LS-E27912 from LifeSpan Bioscience
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Recombinant Human PRMT6 Protein - H00055170-P01 from Novus Biologicals
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Recombinant Human PRMT6 Protein - H00055170-Q01 from Novus Biologicals
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PRMT6 Peptide - P0149 from Novus Biologicals
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PRMT6-Antibody-N-term-Blocking-Peptide - BP1009a from Abgent, a WuXi AppTec company
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Human PRMT 6 protein - orb83616 from Biorbyt
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PRMT6 Blocking Peptide - 33R-3040 from Fitzgerald
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PRMT6 Blocking Peptide - 33R-10623 from Fitzgerald
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PRMT6 Peptide - AC21-2685-P from Abcore
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PRMT6 / HRMT1L6 - H00055170-P01-10 from Acris Antibodies
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PRMT6 / HRMT1L6 - H00055170-P01-25 from Acris Antibodies
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PRMT6 / HRMT1L6 - H00055170-Q01-10 from Acris Antibodies
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PRMT6 / HRMT1L6 - H00055170-Q01-25 from Acris Antibodies
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PRMT6 Peptide - 43-055P from ProSci
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PRMT6 fusion protein - Ag7592 from Proteintech Group
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PRMT6 fusion protein - ag7934 from Proteintech Group
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Recombinant PRMT6 protein - 31394 from ActiveMotif
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Recombinant Human Protein Arginine Methyltransferase 6 - PRMT6-453H from Creative Biomart
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Recombinant Human Protein Arginine Methyltransferase 6, Flag-tagged - PRMT6-653H from Creative Biomart
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