PRMT6

Gene Symbol PRMT6
Entrez Gene 55170
Alt Symbol HRMT1L6
Species Human
Gene Type protein-coding
Description protein arginine methyltransferase 6
Other Description HMT1 hnRNP methyltransferase-like 6|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6|histone-arginine N-methyltransferase PRMT6|protein arginine N-methyltransferase 6
Swissprots Q5T5Y5 Q6DKI4 Q96LA8 Q9NVR8 B4DID8 A3KME1
Accessions EAW51248 Q96LA8 AI754232 AK001421 BAA91681 AK226009 AK295541 BAG58450 AK297898 BAG60218 AY043278 AAK85733 BC002729 AAH02729 BC013866 BC063446 AAH63446 BC073866 AAH73866 DA073209 NM_018137 NP_060607
Function Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enha
Subcellular Location Nucleus {ECO:0000269|PubMed:11724789}.
Tissue Specificity Highly expressed in kidney and testis. {ECO:0000269|PubMed:11724789}.

PRMT6 (D5A2N) Rabbit mAb - 14641 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5A2N
Western blot analysis of extracts from various cell lines using PRMT6 (D5A2N) Rabbit mAb.

PRMT6 (D-5) - sc-271744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRMT6 (D-5): sc-271744. Western blot analysis of PRMT6 expression in non-transfected 293T: sc-117752 (A), mouse PRMT6 transfected 293T: sc-122781 (B), U-2 OS (C) and HeLa (D) whole cell lysates.

PRMT6 (Q-16) - sc-55702 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PRMT6 (Q-16): sc-55702. Western blot analysis of PRMT6 expression in NIH/3T3 (A) and KNRK (B) nuclear extracts.

PRMT6 (H-2) - sc-365018 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRMT6 (H-2): sc-365018. Western blot analysis of PRMT6 expression in KNRK (A) and HeLa (B) nuclear extracts.

PRMT6 (H-130) - sc-134924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRMT6 (H-130): sc-134924. Western blot analysis of PRMT6 expression in NIH/3T3 (A) and KNRK (B) nuclear extracts.

PRMT6 (Y-17) - sc-55703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PRMT6 antibody - ab104834 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab104834 (1/200) staining PRMT6 in HeLa cells (green). Cells were fixed in paraformaldehyde, permeabilised in 0.5% Triton X-100/ PBS and counterstained with DAPI in order to highlight the nucleus (red). For further experimental details please refer to Abreview.See Abreview

Anti-PRMT6 antibody - ab59890 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PRMT6 antibody (ab59890) at 1/100 dilution + human brain extract

Anti-PRMT6 antibody - ab12192 from Abcam

Prices $373.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT6 antibody - ab47244 from Abcam

Prices $382.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-PRMT6 antibody (ab47244) at 1/500 dilution + HeLa cell lysate at 20 µg

Anti-PRMT6 antibody [2C3-F1-G1] - ab151191 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C3-F1-G1
Immunohistochemical staining of paraffin-embedded human breast cancer using anti-PRMT6 (ab151191)  at a dilution of 1:200.

Anti-PRMT6 Antibody (aa1-50) - LS-C89283 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT6 Antibody (C-Terminus) - LS-C89284 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT6 Antibody - LS-C146846 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT6 Antibody (aa1-50) - LS-C287765 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT6 Antibody - LS-C332060 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT6 Antibody (aa275-324) - LS-C110491 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRMT6 antibody LS-C110491 Western blot of 293T cell lysate.

Anti-PRMT6 Antibody (C-Terminus) - LS-C145770 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRMT6 antibody LS-C145770 Western blot of Rat Muscle lysate. Antibody concentration 1 ug/ml.

Anti-PRMT6 Antibody (clone 4G2) - LS-C169197 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G2
Western blot using PRMT6 mouse monoclonal antibody against A431 (1), HeLa (2), A549 (3) and HEK293 (4) cell lysate.

Anti-PRMT6 Antibody - LS-C178302 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot detection of PRMT6 in Hela&293T cell lysates using PRMT6 antibody (1:1000 diluted).

Anti-PRMT6 Antibody (aa42-53) - LS-C155021 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
PRMT6 antibody (0.5 ug/ml) staining of MCF7 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PRMT6 Antibody (C-Terminus) - LS-C287767 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PRMT6 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PRMT6 used at a dilution of 1:5000 (0.2 ug/ml). Detection: DAB.

Anti-PRMT6 Antibody IHC-plus™ - LS-B118 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PRMT6 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B118 dilution 1:100.

Anti-PRMT6 Antibody (aa19-48) - LS-C96514 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-PRMT6 Antibody (C-Terminus) - LS-C286702 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse PRMT6 by Immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-PRMT6 used at a dilution of 1:250. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.
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