PRMT6

Gene Symbol PRMT6
Entrez Gene 55170
Alt Symbol HRMT1L6
Species Human
Gene Type protein-coding
Description protein arginine methyltransferase 6
Other Description HMT1 hnRNP methyltransferase-like 6|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6|histone-arginine N-methyltransferase PRMT6|protein arginine N-methyltransferase 6
Swissprots Q5T5Y5 Q6DKI4 Q96LA8 Q9NVR8 B4DID8 A3KME1
Accessions EAW51248 Q96LA8 AI754232 AK001421 BAA91681 AK226009 AK295541 BAG58450 AK297898 BAG60218 AY043278 AAK85733 BC002729 AAH02729 BC013866 BC063446 AAH63446 BC073866 AAH73866 DA073209 NM_018137 NP_060607
Function Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enha
Subcellular Location Nucleus {ECO:0000269|PubMed:11724789}.
Tissue Specificity Highly expressed in kidney and testis. {ECO:0000269|PubMed:11724789}.

PRMT6 CRISPR/Cas9 KO Plasmid (h) - sc-403433 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRMT6 HDR Plasmid (h) - sc-403433-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRMT6 Double Nickase Plasmid (h) - sc-403433-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRMT6 Double Nickase Plasmid (h2) - sc-403433-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRMT6 CRISPR Activation Plasmid (h) - sc-403433-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRMT6 CRISPR Activation Plasmid (h2) - sc-403433-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRMT6 Lentiviral Activation Particles (h) - sc-403433-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRMT6 Lentiviral Activation Particles (h2) - sc-403433-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRMT6 siRNA (h) - sc-106848 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRMT6 shRNA Plasmid (h) - sc-106848-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRMT6 shRNA (h) Lentiviral Particles - sc-106848-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRMT6 RNAi - H00055170-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU125311 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17445 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17445 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09597 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09597

PRMT6 siRNA (Human) - CRJ0523 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PRMT6 (NM_018137.2) - SHH383368 from Creative biogene

Category siRNA
Species Reactivities Human

PRMT6 shRNA Plasmid (Human) - CHJ0523 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PRMT6 miRNA 3'UTR clone - MiUTR3H-09882 from Creative biogene

Species Reactivities Human
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