| Gene Symbol |
BHLHE41
|
| Entrez Gene |
79365
|
| Alt Symbol |
BHLHB3, DEC2, SHARP1, hDEC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
basic helix-loop-helix family, member e41
|
| Other Description |
basic helix-loop-helix domain containing, class B, 3|class E basic helix-loop-helix protein 41|differentially expressed in chondrocytes protein 2|enhancer-of-split and hairy-related protein 1
|
| Swissprots |
A2I2N8 Q9C0J9
|
| Accessions |
ABM64207 EAW96527 EAW96528 Q9C0J9 AB044088 BAB21502 AJ270695 AK303677 BAH14012 AK311258 AW500664 AY665466 AAV54601 AY665467 AAV54602 BC025968 AAH25968 NM_030762 NP_110389
|
| Function |
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. {ECO:0000269|PubMed:11278948, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|Pu
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
|
| Tissue Specificity |
Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.
|
| Top Pathways |
Circadian rhythm
|