BHLHE41
| Gene Symbol | BHLHE41 |
|---|---|
| Entrez Gene | 79365 |
| Alt Symbol | BHLHB3, DEC2, SHARP1, hDEC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | basic helix-loop-helix family, member e41 |
| Other Description | basic helix-loop-helix domain containing, class B, 3|class E basic helix-loop-helix protein 41|differentially expressed in chondrocytes protein 2|enhancer-of-split and hairy-related protein 1 |
| Swissprots | A2I2N8 Q9C0J9 |
| Accessions | ABM64207 EAW96527 EAW96528 Q9C0J9 AB044088 BAB21502 AJ270695 AK303677 BAH14012 AK311258 AW500664 AY665466 AAV54601 AY665467 AAV54602 BC025968 AAH25968 NM_030762 NP_110389 |
| Function | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. {ECO:0000269|PubMed:11278948, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|Pu |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}. |
| Tissue Specificity | Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney. |
| Top Pathways | Circadian rhythm |
DEC2 CRISPR/Cas9 KO Plasmid (h) - sc-402891 from Santa Cruz Biotechnology
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DEC2 HDR Plasmid (h) - sc-402891-HDR from Santa Cruz Biotechnology
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DEC2 Double Nickase Plasmid (h) - sc-402891-NIC from Santa Cruz Biotechnology
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DEC2 Double Nickase Plasmid (h2) - sc-402891-NIC-2 from Santa Cruz Biotechnology
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DEC2 CRISPR Activation Plasmid (h) - sc-402891-ACT from Santa Cruz Biotechnology
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DEC2 CRISPR Activation Plasmid (h2) - sc-402891-ACT-2 from Santa Cruz Biotechnology
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DEC2 Lentiviral Activation Particles (h) - sc-402891-LAC from Santa Cruz Biotechnology
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DEC2 Lentiviral Activation Particles (h2) - sc-402891-LAC-2 from Santa Cruz Biotechnology
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DEC2 siRNA (h) - sc-37769 from Santa Cruz Biotechnology
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DEC2 shRNA Plasmid (h) - sc-37769-SH from Santa Cruz Biotechnology
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DEC2 shRNA (h) Lentiviral Particles - sc-37769-V from Santa Cruz Biotechnology
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DEC2/SHARP1 RNAi - H00079365-R01 from Novus Biologicals
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MISSION® esiRNA - EHU016921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3970 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3970 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10927 from Sigma-Aldrich
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BHLHE41 siRNA (Human) - CRJ2373 from Cohesion Biosciences
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BHLHE41 - MBS8213096 from MyBioSource
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shRNA set against Human BHLHE41 (NM_030762.2) - SHH246618 from Creative biogene
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Human BHLHE41 siRNA - orb272874 from Biorbyt
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BHLHE41 shRNA Plasmid (Human) - CHJ2373 from Cohesion Biosciences
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