BHLHE41

Gene Symbol	BHLHE41
Entrez Gene	79365
Alt Symbol	BHLHB3, DEC2, SHARP1, hDEC2
Species	Human
Gene Type	protein-coding
Description	basic helix-loop-helix family, member e41
Other Description	basic helix-loop-helix domain containing, class B, 3|class E basic helix-loop-helix protein 41|differentially expressed in chondrocytes protein 2|enhancer-of-split and hairy-related protein 1
Swissprots	A2I2N8 Q9C0J9
Accessions	ABM64207 EAW96527 EAW96528 Q9C0J9 AB044088 BAB21502 AJ270695 AK303677 BAH14012 AK311258 AW500664 AY665466 AAV54601 AY665467 AAV54602 BC025968 AAH25968 NM_030762 NP_110389
Function	Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. {ECO:0000269|PubMed:11278948, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|Pu
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Tissue Specificity	Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.
Top Pathways	Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SHARP1 protein fragment - ab164019 from Abcam Category Protein Source Wheat germ Species Human

BHLHE41 / BHLHB3 / SHARP1 Antibody Blocking Peptide - LS-E14367 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BHLHE41 / BHLHB3 / SHARP1 Antibody Blocking Peptide - LS-E7960 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BHLHE41 / BHLHB3 / SHARP1 Antibody Blocking Peptide - LS-E11866 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DEC2/SHARP1 Protein - H00079365-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BHLH3-Antibody-N-term-Blocking-peptide - BP5748a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BHLHB3 / BHLHE41 - H00079365-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BHLHB3 / BHLHE41 - H00079365-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BHLHE41 fusion protein - ag3381 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SHARP1 Blocking Peptide - CBP3433 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

DEC2 (K31) Peptide - BS2357P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Class E basic helix-loop-helix protein 41(BHLHE41) - CSB-YP883658HU CSB-EP883658HU CSB-BP883658HU CSB-MP883658HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SHARP1 Blocking Peptide - abx162295 from Abbexa Category Peptide Species Human, Mouse, Rat

BHLHE41 Peptide, Human - M34GP01433H from Creative Peptides Category Peptide Source Synthetic. Species Human

DEC2/SHARP1 Recombinant Protein Antigen - NBP2-58737PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Class E basic helix-loop-helix protein 41 (BHLHE41), Recombinant Protein - MBS1453651 from MyBioSource Category Protein Prices $1,265.00, $1,265.00, $1,485.00, $1,485.00, $2,070.00, $2,070.00, $2,535.00, $2,535.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SHARP1 Peptide - orb224319 from Biorbyt Category Peptide Species Human, Mouse, Rat

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