BHLHE41

Gene Symbol BHLHE41
Entrez Gene 79365
Alt Symbol BHLHB3, DEC2, SHARP1, hDEC2
Species Human
Gene Type protein-coding
Description basic helix-loop-helix family, member e41
Other Description basic helix-loop-helix domain containing, class B, 3|class E basic helix-loop-helix protein 41|differentially expressed in chondrocytes protein 2|enhancer-of-split and hairy-related protein 1
Swissprots A2I2N8 Q9C0J9
Accessions ABM64207 EAW96527 EAW96528 Q9C0J9 AB044088 BAB21502 AJ270695 AK303677 BAH14012 AK311258 AW500664 AY665466 AAV54601 AY665467 AAV54602 BC025968 AAH25968 NM_030762 NP_110389
Function Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. {ECO:0000269|PubMed:11278948, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|Pu
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
Tissue Specificity Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.
Top Pathways Circadian rhythm

DEC2 (E-4) - sc-373763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DEC2 (E-4): sc-373763. Western blot analysis of DEC2 expression in SH-SY5Y (A) and IMR-32 (B) nuclear extracts.

DEC2 (H-72) - sc-32853 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

DEC2 (M-20) - sc-25924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DEC2 (M-65) - sc-32854 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

DEC2 (S-18) - sc-25922 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SHARP1 antibody - ab69986 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SHARP1 antibody (ab69986) at 1/500 dilutionLane 1 : Extracts from RAW264.7 cells (5-30µg)Lane 2 : Extracts from RAW264.7 cells (5-30µg), plus immunising peptide (5-10µg)

Anti-SHARP1 antibody - ab82825 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SHARP1 antibody (ab82825) at 1/500 dilution + SH-SY5Y nuclear extract at 30 µgSecondaryAnti-Rabbit IgG HRP at 1/1000 dilution

Anti-SHARP1 antibody - ab57739 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57739 SHARP1 antibody at 1ug/ml.

Anti-SHARP1 antibody - ab118727 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SHARP1 antibody (ab118727) at 1 µg/ml + Rat Liver lysate at 10 µg

Anti-SHARP1 antibody - N-terminal - ab175544 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SHARP1 antibody - N-terminal (ab175544) at 1/1000 dilution + RD cell lysate at 35 µg

Anti-SHARP1 antibody - N-terminal - ab190093 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded Human skin sections labeling SHARP1 with ab190093 at 10 µg/ml.

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa24-54, FITC) - LS-C252552 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa24-54, APC) - LS-C252551 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa24-54, Azide-free, HRP) - LS-C252553 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa24-54, PE) - LS-C252554 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa24-54) - LS-C329257 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa203-283) - LS-C306542 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-50) IHC-plus™ - LS-B9149 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE)

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-297, clone 4E10) - LS-C339821 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BHLHE41 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BHLHE41.

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-297, clone 11B5) - LS-C339911 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11B5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BHLHE41 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BHLHE41.

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-297, clone 7B5) - LS-C339960 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BHLHE41 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BHLHE41.

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-297, clone 8H5) - LS-C339963 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8H5
IHC of paraffin-embedded Human pancreas tissue using anti-BHLHE41 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-297, clone 3H3) - LS-C339958 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H3
IHC of paraffin-embedded Human Kidney tissue using anti-BHLHE41 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-297, clone 3H4) - LS-C339943 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H4
IHC of paraffin-embedded Human tonsil using anti-BHLHE41 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-BHLHE41 / BHLHB3 / SHARP1 Antibody (aa1-297, clone 8H2) - LS-C339965 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8H2
IHC of paraffin-embedded Human pancreas tissue using anti-BHLHE41 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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