| Gene Symbol |
ESPL1
|
| Entrez Gene |
9700
|
| Alt Symbol |
ESP1, SEPA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
extra spindle pole bodies homolog 1 (S. cerevisiae)
|
| Other Description |
caspase-like protein ESPL1|extra spindle poles like 1|extra spindle poles-like 1 protein|separin|separin, cysteine protease
|
| Swissprots |
Q14674
|
| Accessions |
EAW96681 EAW96682 Q14674 AI458447 AK128350 AK299423 BAG61403 AK316135 BAH14506 AW009863 AY455930 AAR18247 BC047603 BC172238 AAI72238 BC172570 AAI72570 BG328178 BP244662 D79987 BAA11482 XM_006719705 XP_006719768 XM_011539024 XP_011537326 XM_011539025 XP_011537327 XR_944842 NM_012291 NP_036423
|
| Function |
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Top Pathways |
Cell cycle, Oocyte meiosis
|