Gene Symbol | ESPL1 |
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Entrez Gene | 9700 |
Alt Symbol | ESP1, SEPA |
Species | Human |
Gene Type | protein-coding |
Description | extra spindle pole bodies homolog 1 (S. cerevisiae) |
Other Description | caspase-like protein ESPL1|extra spindle poles like 1|extra spindle poles-like 1 protein|separin|separin, cysteine protease |
Swissprots | Q14674 |
Accessions | EAW96681 EAW96682 Q14674 AI458447 AK128350 AK299423 BAG61403 AK316135 BAH14506 AW009863 AY455930 AAR18247 BC047603 BC172238 AAI72238 BC172570 AAI72570 BG328178 BP244662 D79987 BAA11482 XM_006719705 XP_006719768 XM_011539024 XP_011537326 XM_011539025 XP_011537327 XR_944842 NM_012291 NP_036423 |
Function | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
Subcellular Location | Cytoplasm. Nucleus. |
Top Pathways | Cell cycle, Oocyte meiosis |
Separase (H-300) - sc-25839 from Santa Cruz Biotechnology
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Separase (B-4) - sc-390314 from Santa Cruz Biotechnology
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Separase (C-20) - sc-27219 from Santa Cruz Biotechnology
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Separase (N-15) - sc-27217 from Santa Cruz Biotechnology
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p-Separase (Ser 1073) - sc-130217 from Santa Cruz Biotechnology
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Anti-Separase (phospho S1176) antibody - ab59991 from Abcam
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Anti-Separase (phospho S1501) antibody - ab60027 from Abcam
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Anti-Separase (phospho S748) antibody - ab59992 from Abcam
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Anti-Separase (phospho S801) antibody - ab52210 from Abcam
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Anti-Separase antibody - ab3762 from Abcam
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Anti-Separase antibody - ab199153 from Abcam
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Anti-Separase antibody - ab52158 from Abcam
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Anti-Separase antibody - ab85685 from Abcam
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Anti-Separase antibody [2329C1a] - ab84868 from Abcam
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Anti-Separase antibody [XJ11-1B12] - ab16170 from Abcam
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Anti-ESPL1 / Separase Antibody (Ser1126, AP) - LS-C282621 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (Ser1126, Biotin) - LS-C282623 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (Ser1126, APC) - LS-C282622 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (Ser1126, Azide-free, HRP) - LS-C282624 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (Ser1126, FITC) - LS-C282626 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (Ser1126, PE) - LS-C282627 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (aa1100-1150) - LS-C288966 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (Ser1176, Biotin) - LS-C284695 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (aa1425-1475) - LS-C288970 from LifeSpan Bioscience
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Anti-ESPL1 / Separase Antibody (phospho-Ser748) - LS-C328625 from LifeSpan Bioscience
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