RXRA

Gene Symbol RXRA
Entrez Gene 6256
Alt Symbol NR2B1
Species Human
Gene Type protein-coding
Description retinoid X receptor, alpha
Other Description nuclear receptor subfamily 2 group B member 1|retinoic acid receptor RXR-alpha|retinoid X nuclear receptor alpha
Swissprots Q2V504 B3KY83 P19793 Q2NL52
Accessions ABB96254 CBX47611 EAW88122 EAW88123 EAW88124 EAW88125 P19793 AB307705 BAH02296 AF052092 AK090416 BAC03397 AK131081 BAC85131 AK131192 BAG54745 AK131513 BC007925 BC009882 BC031356 BC063827 AAH63827 BC096246 BC110998 AAI10999 BM563384 BP422254 BQ220698 BQ637722 CN391132 EU446653 ABZ92182 HQ692843 ADZ17354 U66306 AAC31116 X52773 CAA36982 NM_001291920 NP_001278849 NM_001291921 NP_001278850 NM_002957 NP_002948
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXR
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:11915042}.
Tissue Specificity Highly expressed in liver, also found in lung, kidney and heart.
Top Pathways Hepatitis C, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway, Bile secretion, Small cell lung cancer

RXRα Antibody - 5388 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using RXRα Antibody.

RXRα (D6H10) Rabbit mAb - 3085 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6H10
Western blot analysis of extracts from various cell lines using RXRα (D6H10) Rabbit mAb.

RXR (ΔN 197) - sc-774 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RXR (ΔN 197): sc-774. Western blot analysis of 10 ng of purified human RXRβ.

RXRα (D-20) - sc-553 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RXRα (D-20): sc-553. Western blot analysis of RXRα expression in HeLa nuclear extracts.

RXRα (F-1) - sc-46659 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RXRα (F-1): sc-46659. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing nuclear staining of cells in white and red pulps. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Anti-Retinoid X Receptor alpha antibody - ab80453 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Retinoid X Receptor alpha antibody - ab191176 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-Retinoid X Receptor alpha antibody (ab191176) at 1/1000 dilution + MCF7 cell lysate at 35 µg

Anti-Retinoid X Receptor alpha antibody - ab118329 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HepG2 cells stained with ab118329 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab118329, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Retinoid X Receptor alpha antibody - ab24363 from Abcam

Prices $379.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Retinoid X Receptor alpha antibody (ab24363) at 0.3 µg/ml + Nuclear HeLa lysate at 35 µg

Anti-Retinoid X Receptor alpha antibody - ab86027 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Retinoid X Receptor alpha antibody (ab86027) at 1/1000 dilutionLane 1 : An un-induced culture of E. coliLane 2 : An induced culture of E. coliLysates/proteins at 1/5000 dilution per lane.SecondaryAnti-Rabbit IgG HRP at 1/1000 dilution

Anti-Retinoid X Receptor alpha antibody - ab172316 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Retinoid X Receptor alpha antibody (ab172316) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with Retinoid X Receptor alphaLane 2 : Lysate from non-transfected 293T cellsLysates/proteins at 15 µl per lane.

Anti-Retinoid X Receptor alpha antibody - ab28435 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Retinoid X Receptor alpha antibody [EPR7106] - ab125001 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7106
All lanes : Anti-Retinoid X Receptor alpha antibody [EPR7106] (ab125001) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : HeLa cell lysateLane 3 : K562 cell lysateLane 4 : RAW 264.7 cell lysateLane 5 : PC12 cell lysateLane 6 : NIH 3T3 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-RXTA / RXR-Alpha Antibody - LS-C126243 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-RXTA / RXR-Alpha Antibody (aa68-82) - LS-C20207 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
(0.5 ug/ml) Staining of A431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-RXTA / RXR-Alpha Antibody (aa362-411) - LS-C80051 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-RXTA / RXR-Alpha Antibody (N-Terminus) - LS-C80592 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-RXTA / RXR-Alpha Antibody (aa196-224, AP) - LS-C285180 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RXTA / RXR-Alpha Antibody (aa38-87) - LS-C80082 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-RXTA / RXR-Alpha Antibody (aa196-224, Biotin) - LS-C285181 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RXTA / RXR-Alpha Antibody (aa196-224, APC) - LS-C285182 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RXTA / RXR-Alpha Antibody (aa196-224, PE) - LS-C285185 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RXTA / RXR-Alpha Antibody (aa196-224, Azide-free, HRP) - LS-C285184 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RXTA / RXR-Alpha Antibody (aa196-224, FITC) - LS-C285183 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RXTA / RXR-Alpha Antibody (aa200-230) - LS-C330088 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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