RXRA

Gene Symbol	RXRA
Entrez Gene	6256
Alt Symbol	NR2B1
Species	Human
Gene Type	protein-coding
Description	retinoid X receptor, alpha
Other Description	nuclear receptor subfamily 2 group B member 1|retinoic acid receptor RXR-alpha|retinoid X nuclear receptor alpha
Swissprots	Q2V504 B3KY83 P19793 Q2NL52
Accessions	ABB96254 CBX47611 EAW88122 EAW88123 EAW88124 EAW88125 P19793 AB307705 BAH02296 AF052092 AK090416 BAC03397 AK131081 BAC85131 AK131192 BAG54745 AK131513 BC007925 BC009882 BC031356 BC063827 AAH63827 BC096246 BC110998 AAI10999 BM563384 BP422254 BQ220698 BQ637722 CN391132 EU446653 ABZ92182 HQ692843 ADZ17354 U66306 AAC31116 X52773 CAA36982 NM_001291920 NP_001278849 NM_001291921 NP_001278850 NM_002957 NP_002948
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXR
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:11915042}.
Tissue Specificity	Highly expressed in liver, also found in lung, kidney and heart.
Top Pathways	Hepatitis C, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway, Bile secretion, Small cell lung cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Retinoid X Receptor alpha full length protein - ab82050 from Abcam Category Protein Source E. coli Species Human

Human Retinoid X Receptor alpha peptide - ab45626 from Abcam Category Peptide Species Human

Human Retinoid X Receptor alpha protein fragment - ab48737 from Abcam Category Protein Source E. coli Species Human

Human Retinoid X Receptor alpha protein fragment - ab81882 from Abcam Category Protein Source E. coli Species Human

Human Retinoid X Receptor alpha protein fragment - ab84128 from Abcam Category Protein Source E. coli Species Human

RXR alpha/NR2B1 Partial Recombinant Protein - H00006256-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RXR alpha/NR2B1 Protein - H00006256-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human RXR alpha/NR2B1 Protein - NBC1-18416 from Novus Biologicals Category Protein Prices $249.00 Sizes 100 µg Source E.coli Species Human

RXR alpha/NR2B1 Recombinant Protein - H00006256-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RXRA-Antibody-Center-Blocking-Peptide - BP4920c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Retinoid X Receptor alpha blocking peptide - GTX89652-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

RXRA Protein (OPPA01347) - OPPA01347 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human Retinoid Receptor Alpha protein - orb81331 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli

RXRA Blocking Peptide - 33R-2196 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RXRA Blocking Peptide - 33R-5845 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RXRA Blocking Peptide - 33R-2195 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RXRalpha protein - 30R-1037 from Fitzgerald Category Protein Prices $250.00 Sizes 100 µg Source E.coli

Retinoid X Receptor alpha Peptide - AC21-0608-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RXR-alpha / RXRA (111-228) - SA6040 from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

RXR-alpha / RXRA (111-228) - SA6040X from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

RXR-alpha / RXRA - H00006256-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RXR-alpha / RXRA - H00006256-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RXR-alpha / RXRA - H00006256-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RXR-alpha / RXRA - H00006256-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RXR-alpha / RXRA - H00006256-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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