| Gene Symbol |
RXRA
|
| Entrez Gene |
6256
|
| Alt Symbol |
NR2B1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoid X receptor, alpha
|
| Other Description |
nuclear receptor subfamily 2 group B member 1|retinoic acid receptor RXR-alpha|retinoid X nuclear receptor alpha
|
| Swissprots |
Q2V504 B3KY83 P19793 Q2NL52
|
| Accessions |
ABB96254 CBX47611 EAW88122 EAW88123 EAW88124 EAW88125 P19793 AB307705 BAH02296 AF052092 AK090416 BAC03397 AK131081 BAC85131 AK131192 BAG54745 AK131513 BC007925 BC009882 BC031356 BC063827 AAH63827 BC096246 BC110998 AAI10999 BM563384 BP422254 BQ220698 BQ637722 CN391132 EU446653 ABZ92182 HQ692843 ADZ17354 U66306 AAC31116 X52773 CAA36982 NM_001291920 NP_001278849 NM_001291921 NP_001278850 NM_002957 NP_002948
|
| Function |
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXR
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:11915042}.
|
| Tissue Specificity |
Highly expressed in liver, also found in lung, kidney and heart.
|
| Top Pathways |
Hepatitis C, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway, Bile secretion, Small cell lung cancer
|