RXRA

Gene Symbol	RXRA
Entrez Gene	6256
Alt Symbol	NR2B1
Species	Human
Gene Type	protein-coding
Description	retinoid X receptor, alpha
Other Description	nuclear receptor subfamily 2 group B member 1|retinoic acid receptor RXR-alpha|retinoid X nuclear receptor alpha
Swissprots	Q2V504 B3KY83 P19793 Q2NL52
Accessions	ABB96254 CBX47611 EAW88122 EAW88123 EAW88124 EAW88125 P19793 AB307705 BAH02296 AF052092 AK090416 BAC03397 AK131081 BAC85131 AK131192 BAG54745 AK131513 BC007925 BC009882 BC031356 BC063827 AAH63827 BC096246 BC110998 AAI10999 BM563384 BP422254 BQ220698 BQ637722 CN391132 EU446653 ABZ92182 HQ692843 ADZ17354 U66306 AAC31116 X52773 CAA36982 NM_001291920 NP_001278849 NM_001291921 NP_001278850 NM_002957 NP_002948
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXR
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:11915042}.
Tissue Specificity	Highly expressed in liver, also found in lung, kidney and heart.
Top Pathways	Hepatitis C, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway, Bile secretion, Small cell lung cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® RXRα siRNA I - 6348 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

RXRα CRISPR/Cas9 KO Plasmid (h) - sc-400342 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RXRα HDR Plasmid (h) - sc-400342-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RXRα Double Nickase Plasmid (h) - sc-400342-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RXRα Double Nickase Plasmid (h2) - sc-400342-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RXRα CRISPR Activation Plasmid (h) - sc-400342-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RXRα CRISPR Activation Plasmid (h2) - sc-400342-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RXRα Lentiviral Activation Particles (h) - sc-400342-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RXRα Lentiviral Activation Particles (h2) - sc-400342-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RXRα siRNA (h) - sc-36447 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RXRα shRNA Plasmid (h) - sc-36447-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RXRα shRNA (h) Lentiviral Particles - sc-36447-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RXR alpha/NR2B1 RNAi - H00006256-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU101611 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU153261 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18773 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18773 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

RXRA siRNA (Human) - CRH4212 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RXRA - MBS829595 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RXRA (NM_002957.4) - SHH400972 from Creative biogene Category siRNA Species Reactivities Human

Human RXRA siRNA - orb264714 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RXRA shRNA Plasmid (Human) - CHH4212 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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