AIM2

Gene Symbol AIM2
Entrez Gene 9447
Alt Symbol PYHIN4
Species Human
Gene Type protein-coding
Description absent in melanoma 2
Other Description interferon-inducible protein AIM2
Swissprots O14862 Q96FG9 A8K7M7 Q5T3V9
Accessions CCQ43285 EAW52795 O14862 AF024714 AAB81613 AK292042 BAF84731 BC010940 AAH10940 U52053 XM_005245616 XP_005245673 XM_005245617 XP_005245674 NM_004833 NP_004824
Function Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:16432157, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831}.
Subcellular Location Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Tissue Specificity Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. {ECO:0000269|PubMed:9242382}.
Top Pathways Cytosolic DNA-sensing pathway

AIM2 Antibody (Mouse Specific) - 13095 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS-7 cells, mock transfected (-) or transfected with a construct expressing mouse AIM2 (mAIM2; +), using AIM2 Antibody (Mouse Specific).

AIM2 (D5X7K) Rabbit mAb - 12948 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5X7K
Western blot analysis of extracts from Daudi, KARPAS-299, and L-540 cell lines using AIM2 (D5X7K) Rabbit mAb.

AIM2 Antibody - 8055 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HL-60 cells, serum-starved and either untreated (-) or treated overnight with Human Interferon-γ (hIFN-γ) #8901 (100 ng/ml), using AIM2 Antibody.

AIM2 (N-15) - sc-137971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

AIM2 (K-12) - sc-137970 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
AIM2 (K-12): sc-137970. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Anti-AIM2 antibody - ab93015 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of AIM2 in formalin fixed, paraffin embedded Human fetal tonsil showing nuclear staining with ab93015 at a dilution of 1/100.

Anti-AIM2 antibody - ab76423 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-AIM2 antibody (ab76423) at 1 µg/ml (in 5% skim milk / PBS buffer) + Fetal lung lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-AIM2 antibody - ab119791 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AIM2 antibody (ab119791) at 1/1000 dilutionLane 1 : Human Jurkat cellsLane 2 : Mouse macrophages, untreatedLane 3 : Mouse macrophages, treated with IFN gamma (10 ng/ml) and LPS (1mg/ml) for 12 hr Lysates/proteins at 20 µg per lane.

Anti-AIM2 antibody - ab135914 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AIM2 antibody (ab135914) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-AIM2 antibody - ab172343 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-AIM2 antibody (ab172343) at 1 µg/mlLane 1 : AIM2 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-AIM2 antibody - ab186043 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-AIM2 antibody (ab186043) at 0.3 µg/ml + Daudi cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-AIM2 Antibody (clone IMG10M2B3) - LS-C148810 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone IMG10M2B3

Anti-AIM2 Antibody (clone IMG10M5G5) - LS-C148811 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone IMG10M5G5

Anti-AIM2 Antibody (Ala78) - LS-C192022 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AIM2 Antibody (aa15-27) - LS-C186440 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-AIM2 Antibody (N-Terminus) - LS-C81558 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal lung lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-AIM2 Antibody (aa89-103) - LS-C204963 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-AIM2 Antibody (aa4-32, APC) - LS-C251074 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AIM2 Antibody (aa4-32, AP) - LS-C251072 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AIM2 Antibody (aa4-32, Biotin) - LS-C251075 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AIM2 Antibody (aa4-32, FITC) - LS-C251076 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AIM2 Antibody (aa4-32, PE) - LS-C251078 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AIM2 Antibody - LS-C306161 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-AIM2 Antibody - LS-C309372 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AIM2 Antibody (Internal) - LS-C137125 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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