AIM2

Gene Symbol AIM2
Entrez Gene 9447
Alt Symbol PYHIN4
Species Human
Gene Type protein-coding
Description absent in melanoma 2
Other Description interferon-inducible protein AIM2
Swissprots O14862 Q96FG9 A8K7M7 Q5T3V9
Accessions CCQ43285 EAW52795 O14862 AF024714 AAB81613 AK292042 BAF84731 BC010940 AAH10940 U52053 XM_005245616 XP_005245673 XM_005245617 XP_005245674 NM_004833 NP_004824
Function Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:16432157, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831}.
Subcellular Location Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Tissue Specificity Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. {ECO:0000269|PubMed:9242382}.
Top Pathways Cytosolic DNA-sensing pathway

AIM2 CRISPR/Cas9 KO Plasmid (h) - sc-403391 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIM2 HDR Plasmid (h) - sc-403391-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIM2 Double Nickase Plasmid (h) - sc-403391-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIM2 Double Nickase Plasmid (h2) - sc-403391-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIM2 CRISPR Activation Plasmid (h) - sc-403391-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIM2 CRISPR Activation Plasmid (h2) - sc-403391-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIM2 Lentiviral Activation Particles (h) - sc-403391-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIM2 Lentiviral Activation Particles (h2) - sc-403391-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIM2 siRNA (h) - sc-88166 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AIM2 shRNA Plasmid (h) - sc-88166-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AIM2 shRNA (h) Lentiviral Particles - sc-88166-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU015351 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2988 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2988 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01111 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01111

AIM2 siRNA (Human) - CRH6266 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AIM2 - MBS8223463 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human AIM2(NM_004833.1) - SHG048805 from Creative biogene

Category siRNA
Species Reactivities Human

AIM2 shRNA Plasmid (Human) - CHH6266 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AIM2 miRNA 3'UTR clone - MiUTR1H-00258 from Creative biogene

Species Reactivities Human
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