AIM2

Gene Symbol	AIM2
Entrez Gene	9447
Alt Symbol	PYHIN4
Species	Human
Gene Type	protein-coding
Description	absent in melanoma 2
Other Description	interferon-inducible protein AIM2
Swissprots	O14862 Q96FG9 A8K7M7 Q5T3V9
Accessions	CCQ43285 EAW52795 O14862 AF024714 AAB81613 AK292042 BAF84731 BC010940 AAH10940 U52053 XM_005245616 XP_005245673 XM_005245617 XP_005245674 NM_004833 NP_004824
Function	Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:16432157, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831}.
Subcellular Location	Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Tissue Specificity	Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. {ECO:0000269|PubMed:9242382}.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Absent in melanoma 2 Gene - orb92764 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-AIM2-cDNA-Clone - DC03037 from Abgent, a WuXi AppTec company Prices $481.95 Sizes 10 µg Species Human Accession BC010940

AIM2 - MBS1271252 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC010940

Human AIM2 cDNA clone(NM_004833.1) - CDFH000533 from Creative Biomart Species Human Accession NM_004833.1

Human AIM2 ORF clone(NM_004833.1) - CDCL182641 from Creative Biomart Species Human Accession NM_004833.1

Human AIM2 ORF Clone(NM_004833.1) - CDCL153461 from Creative Biomart Species Human Accession NM_004833.1

Human AIM2 ORF Clone(NM_004833.1) - CDCR288952 from Creative Biomart Species Human Accession NM_004833.1

Human AIM2 ORF Clone(NM_004833.1) - CDCR288953 from Creative Biomart Species Human Accession NM_004833.1

Human AIM2 Gene ORF cDNA clone in cloning vector - HG11654-M from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11654-CF from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11654-NM from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11654-NY from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11654-CM from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11654-NH from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11654-ANG from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid - HG11654-UT from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11654-CH from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11654-CY from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11654-ACR from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11654-ANR from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11654-ACG from Sino Biological Species Human

Human AIM2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11654-NF from Sino Biological Species Human

AIM2 - CL01107H01 from Elabscience Species Human Accession NM_004833.1

Human AIM2 ORF clone(NM_004833.1) - CDCL182641 from Creative biogene Species Human

Human AIM2 ORF Clone (BC010940) - CDCS411978 from Creative biogene Species Human Accession O14862

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