AIM2

Gene Symbol	AIM2
Entrez Gene	9447
Alt Symbol	PYHIN4
Species	Human
Gene Type	protein-coding
Description	absent in melanoma 2
Other Description	interferon-inducible protein AIM2
Swissprots	O14862 Q96FG9 A8K7M7 Q5T3V9
Accessions	CCQ43285 EAW52795 O14862 AF024714 AAB81613 AK292042 BAF84731 BC010940 AAH10940 U52053 XM_005245616 XP_005245673 XM_005245617 XP_005245674 NM_004833 NP_004824
Function	Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:16432157, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831}.
Subcellular Location	Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Tissue Specificity	Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. {ECO:0000269|PubMed:9242382}.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AIM2 ELISA Kit (Sandwich ELISA) - LS-F8639 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.156-10 ng/ml

Human Absent In Melanoma 2 ELISA Kit - abx150516 from Abbexa Category ELISA Kit Sensitivity 0.059 ng/ml Range 0.156 ng/ml - 10 ng/ml

Absent In Melanoma 2 (AIM2), Human, ELISA Kit - SEG302Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

Absent In Melanoma 2, AIM2, Human, ELISA Kit - E-EL-H2427 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Interferon-inducible protein AIM2, AIM2, Human, ELISA Kit - E2139h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Absent In Melanoma 2, AIM2, Rabbit, ELISA Kit - E-EL-RB1749 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Absent In Melanoma 2, AIM2, Chicken, ELISA Kit - E-EL-Ch1480 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Absent In Melanoma 2, AIM2, Porcine, ELISA Kit - E-EL-P1835 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Absent In Melanoma 2, AIM2, Monkey, ELISA Kit - E-EL-MK1291 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

AIM2 (Human) IP-WB Antibody Pair - H00009447-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human AIM2(Absent In Melanoma 2) ELISA Kit - E-EL-H2427 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human AIM2 (Absent In Melanoma 2) CLIA Kit - E-CL-H1428 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

absent in melanoma 2, ELISA Kit - MBS9330728 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Absent In Melanoma 2 (AIM2), ELISA Kit - MBS2020469 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.064ng/mL. Range 0.156-10ng/mL

AIM2, ELISA Kit - MBS2502670 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

AIM2, ELISA Kit - MBS2513081 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

AIM2, ELISA Kit - MBS2503613 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

AIM2, ELISA Kit - MBS2514111 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

AIM2, ELISA Kit - MBS2505959 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

interferon-inducible protein 16 (IFI16 / p16), ELISA Kit - MBS269574 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.06 ng/ml. Range 20 ng/ml-3.12 ng/ml

interferon-inducible protein 16 (IFI16 / p16), ELISA Kit - MBS269070 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

interferon-inducible protein 16 (IFI16 / p16), ELISA Kit - MBS260405 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

interferon-inducible protein 16 (IFI16 / p16), ELISA Kit - MBS262532 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

interferon-inducible protein 16 (IFI16 / p16), ELISA Kit - MBS2601349 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

interferon-inducible protein 16 (IFI16 / p16), ELISA Kit - MBS268712 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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