AIM2

Gene Symbol	AIM2
Entrez Gene	9447
Alt Symbol	PYHIN4
Species	Human
Gene Type	protein-coding
Description	absent in melanoma 2
Other Description	interferon-inducible protein AIM2
Swissprots	O14862 Q96FG9 A8K7M7 Q5T3V9
Accessions	CCQ43285 EAW52795 O14862 AF024714 AAB81613 AK292042 BAF84731 BC010940 AAH10940 U52053 XM_005245616 XP_005245673 XM_005245617 XP_005245674 NM_004833 NP_004824
Function	Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:16432157, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831}.
Subcellular Location	Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Tissue Specificity	Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. {ECO:0000269|PubMed:9242382}.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AIM2 protein (His tag) - ab127847 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

AIM2 Antibody Blocking Peptide - LS-E27303 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIM2 Antibody Blocking Peptide - LS-E10367 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIM2 Antibody Blocking Peptide - LS-E28020 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIM2-Antibody-N-term-Blocking-Peptide - BP9876a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AIM2 blocking peptide - GTX88186-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human Absent in melanoma 2 protein - orb84041 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Insect Species Human

AIM2 Blocking Peptide - 33R-2734 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AIM2 Peptide - AC21-2124-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AIM2 - H00009447-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

AIM2 - H00009447-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

AIM2 - H00009447-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

AIM2 Peptide - 42-531P from ProSci Category Peptide Species Human

AIM2 fusion protein - ag14520 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

AIM2 fusion protein - Ag14607 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Recombinant Human AIM2, GST tagged - AIM2-1159H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human AIM2, GST-tagged - AIM2-9507H from Creative Biomart Category Protein Source E.coli Species Human

AIM2 - PN201246 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Baculovirus Species Human

Recombinant Absent In Melanoma 2 (AIM2) - RPG302Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human AIM2 Protein (GST Tag) - 11654-H09B-20 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Human

AIM2 Blocking Peptide - CBP3366 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

AIM2 (A78) Peptide - BS2393P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Absent In Melanoma 2 (AIM2) - RPG302Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Interferon-inducible protein AIM2(AIM2) - CSB-YP001499HU CSB-EP001499HU CSB-BP001499HU CSB-MP001499HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human AIM2 Protein - H00009447-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

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