CES2

Gene Symbol CES2
Entrez Gene 8824
Alt Symbol CE-2, CES2A1, PCE-2, iCE
Species Human
Gene Type protein-coding
Description carboxylesterase 2
Other Description carboxylesterase 2 (intestine, liver)|cocaine esterase|hCE-2|intestinal carboxylesterase; liver carboxylesterase-2|methylumbelliferyl-acetate deacetylase 2
Swissprots Q16859 O00748 Q5MAB8 Q7Z366 Q8TCP8 Q8IUP4 A8K367
Accessions AAW29943 EAW83057 EAW83058 EAW83059 O00748 AI601196 AK095522 AK222724 BAD96444 AK290482 BAF83171 AL713761 CAD28531 AM392781 CAL37659 AU137474 BC032095 AAH32095 BC071874 AAH71874 BC098417 AAH98417 BX538086 CAD98009 D50579 BAA23606 DQ893022 ABM83948 DQ896756 ABM87755 U60553 AAB03611 Y09616 CAA70831 XM_011523421 XP_011521723 NM_003869 NP_003860 NM_198061 NP_932327 NR_036684
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. {ECO:0000269|PubMed:9169443}.
Subcellular Location Endoplasmic reticulum lumen {ECO:0000250}.
Tissue Specificity Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. {ECO:0000269|PubMed:9144407}.
Top Pathways Drug metabolism - other enzymes

CES2 (D-15) - sc-65022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CES2 (G5) - sc-100685 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
CES2 (G5): sc-100685. Western blot analysis of CES2 expression in Hep G2 whole cell lysate.

CES2 (P-18) - sc-65026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CES2 antibody - ab137606 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CES2 antibody (ab137606) at 1/5000 dilution + HepG2 whole cell lysate at 30 µg/ml

Anti-CES2 antibody - ab111751 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CES2 antibody (ab111751) at 1/100 dilution + MCF7 cell lysates at 35 µg

Anti-CES2 antibody - ab126970 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CES2 antibody (ab126970) at 1/2000 dilution + HepG2 whole cell lysate at 30 µg

Anti-CES2 antibody - ab56528 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
CES2 antibody (ab56528) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

Anti-CES2 antibody - ab88439 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-CES2 antibody (ab88439) at 1 µg/ml + human liver tissue lysate at 25 µgdeveloped using the ECL technique

Anti-CES2 antibody [EPR14856] - ab184957 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14856
Anti-CES2 antibody [EPR14856] (ab184957) at 1/1000 dilution + HepG2 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-CES2 antibody - Carboxyterminal end - ab56056 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody - LS-C59308 from LifeSpan Bioscience

Prices $395.00
Sizes 2 ml
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody - LS-C147409 from LifeSpan Bioscience

Prices $270.00
Sizes 10 mg
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody - LS-C125349 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CES2 / Esterase Antibody - LS-C123226 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CES2 / Esterase Antibody (Biotin) - LS-C147410 from LifeSpan Bioscience

Prices $360.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody - LS-C147411 from LifeSpan Bioscience

Prices $455.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody (aa514-622, clone 10B2209, Azide-free) - LS-C183514 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10B2209

Anti-CES2 / Esterase Antibody (aa27-559, clone 1D4B) - LS-C189792 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D4B

Anti-CES2 / Esterase Antibody (aa343-373, AP) - LS-C254650 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody (aa503-552) - LS-C110716 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CES2 / Esterase antibody LS-C110716 Western blot of THP-1 cell lysate.

Anti-CES2 / Esterase Antibody (aa343-373, APC) - LS-C254651 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody (aa343-373, FITC) - LS-C254653 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody (aa343-373, Azide-free, HRP) - LS-C254652 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody (aa343-373, PE) - LS-C254654 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CES2 / Esterase Antibody - LS-C309889 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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