| Gene Symbol |
CES2
|
| Entrez Gene |
8824
|
| Alt Symbol |
CE-2, CES2A1, PCE-2, iCE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carboxylesterase 2
|
| Other Description |
carboxylesterase 2 (intestine, liver)|cocaine esterase|hCE-2|intestinal carboxylesterase; liver carboxylesterase-2|methylumbelliferyl-acetate deacetylase 2
|
| Swissprots |
Q16859 O00748 Q5MAB8 Q7Z366 Q8TCP8 Q8IUP4 A8K367
|
| Accessions |
AAW29943 EAW83057 EAW83058 EAW83059 O00748 AI601196 AK095522 AK222724 BAD96444 AK290482 BAF83171 AL713761 CAD28531 AM392781 CAL37659 AU137474 BC032095 AAH32095 BC071874 AAH71874 BC098417 AAH98417 BX538086 CAD98009 D50579 BAA23606 DQ893022 ABM83948 DQ896756 ABM87755 U60553 AAB03611 Y09616 CAA70831 XM_011523421 XP_011521723 NM_003869 NP_003860 NM_198061 NP_932327 NR_036684
|
| Function |
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. {ECO:0000269|PubMed:9169443}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000250}.
|
| Tissue Specificity |
Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. {ECO:0000269|PubMed:9144407}.
|
| Top Pathways |
Drug metabolism - other enzymes
|
![Western Blot: CES2 Overexpression Lysate (Adult Normal) [NBL1-09114] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CES2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9525_CES2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09114-img0002.jpg)