AGO2

Gene Symbol	AGO2
Entrez Gene	27161
Alt Symbol	EIF2C2, Q10
Species	Human
Gene Type	protein-coding
Description	argonaute RISC catalytic component 2
Other Description	CTA-204B4.6|PAZ Piwi domain protein|PPD|argonaute 2|argonaute2|eIF-2C 2|eIF2C 2|eukaryotic translation initiation factor 2C, 2|hAgo2|protein argonaute-2|protein slicer
Swissprots	Q8WV58 Q96ID1 Q8TCZ5 Q9UKV8
Accessions	CAK32193 EAW92207 EAW92208 Q9UKV8 AA909234 AF121255 AAF13034 AI468419 AK096164 AK130012 AL050151 AY077717 AAL76093 BC007633 AAH07633 BC018727 AAH18727 BC054491 BC065217 BC125213 AAI25214 BC125214 BC160104 AAI60104 BT007229 AAP35893 HG501752 XM_011516964 XP_011515266 XM_011516965 XP_011515267 XM_011516966 XP_011515268 XM_011516967 XP_011515269 XM_011516968 XP_011515270 NM_001164623 NP_001158095 NM_012154 NP_036286
Function	Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t
Subcellular Location	Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Bovine AGO2 / EIF2C2 ELISA Kit (Sandwich ELISA) - LS-F10766 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 15.6 Range 15.6-1000 pg/ml

Protein argonaute-2 (EIF2C2), Human, ELISA Kit - CSB-EL007520HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Protein argonaute-2, EIF2C2, Human, ELISA Kit - E11449h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

eukaryotic translation initiation factor 2C, 2, ELISA Kit - MBS910054 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 6.25 pg/ml Range 25 pg/ml-1600 pg/ml.

Human Protein argonaute-2(EIF2C2) ELISA kit - CSB-EL007520HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human AGO2 / EIF2C2 ELISA Kit (Sandwich ELISA) - LS-F16185 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 Range 15.6-1000 pg/ml

Human Protein argonaute-2 (EIF2C2) ELISA Kit - EKC35179 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human Protein argonaute-2 ELISA Kit - EKE52185 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 31.2-2000 pg/ml

EIF2C2 ELISA Kit (Human) : 96 Wells (OKEH02165) - OKEH02165 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 10 pg/mL Range 31.2 - 2000 pg/mL

Human EIF2C2 ELISA Kit - E013743 from Biobool Category ELISA Kit Sensitivity Typically less than 6.25 pg/ml

Human AGO2 ELISA Kit - E031481 from Biobool Category ELISA Kit

Human Protein argonaute-2 ELISA Kit - EK2835 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 31.2-2000 pg/ml

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9350589 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9357805 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9348404 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9361085 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml Range 0.5 ng/ml - 16 ng/ml

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9357513 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9368344 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9355752 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9346879 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9353377 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9368334 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9365833 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9362731 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Argonaute-2 (AGO2), ELISA Kit - MBS9344554 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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