AGO2

Gene Symbol	AGO2
Entrez Gene	27161
Alt Symbol	EIF2C2, Q10
Species	Human
Gene Type	protein-coding
Description	argonaute RISC catalytic component 2
Other Description	CTA-204B4.6|PAZ Piwi domain protein|PPD|argonaute 2|argonaute2|eIF-2C 2|eIF2C 2|eukaryotic translation initiation factor 2C, 2|hAgo2|protein argonaute-2|protein slicer
Swissprots	Q8WV58 Q96ID1 Q8TCZ5 Q9UKV8
Accessions	CAK32193 EAW92207 EAW92208 Q9UKV8 AA909234 AF121255 AAF13034 AI468419 AK096164 AK130012 AL050151 AY077717 AAL76093 BC007633 AAH07633 BC018727 AAH18727 BC054491 BC065217 BC125213 AAI25214 BC125214 BC160104 AAI60104 BT007229 AAP35893 HG501752 XM_011516964 XP_011515266 XM_011516965 XP_011515267 XM_011516966 XP_011515268 XM_011516967 XP_011515269 XM_011516968 XP_011515270 NM_001164623 NP_001158095 NM_012154 NP_036286
Function	Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t
Subcellular Location	Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

D. melanogaster Ago2 / eIF2C2 peptide - ab24177 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Ago2 / eIF2C2 peptide - ab32380 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Ago2 / eIF2C2 protein fragment - ab132131 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Ago2 / eIF2C2 protein fragment - ab132130 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human Ago2 / eIF2C2 protein fragment - ab153286 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Recombinant Human Ago2/eIF2C2 Protein - H00027161-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Ago2/eIF2C2 Protein - H00027161-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Human AGO2 His tag protein - orb83400 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Insect Species Human

Human AGO2 protein - orb246204 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human AGO2 Partial protein - orb244993 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Source E.coli Species Human

EIF2C2 / AGO2 - H00027161-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

EIF2C2 / AGO2 - H00027161-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

EIF2C2 / AGO2 - H00027161-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EIF2C2 / AGO2 - H00027161-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EIF2C2 / AGO2 - H00027161-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EIF2C2 / AGO2 - H00027161-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

AGO2 fusion protein - ag1032 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

AGO2 fusion protein - Ag17723 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Slicer Peptide - 350549 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant AGO2 protein - 31486 from ActiveMotif Category Protein Prices $395.00, $3,500.00 Sizes 20 µg, 1 mg Source Baculovirus Species Human

Recombinant Human AGO2, His tagged - AGO2-2180H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human EIF2C2, His-tagged - EIF2C2-2180H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human EIF2C2, His-tagged - EIF2C2-12358H from Creative Biomart Category Protein Source E.coli Species Human

AGO2 - PN201237 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Insect cells Species Human

Human AGO2 / Argonaute 2 / EIF2C2 Protein (His Tag) - 11079-H07B-10 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Human

Search more