AGO2

Gene Symbol AGO2
Entrez Gene 27161
Alt Symbol EIF2C2, Q10
Species Human
Gene Type protein-coding
Description argonaute RISC catalytic component 2
Other Description CTA-204B4.6|PAZ Piwi domain protein|PPD|argonaute 2|argonaute2|eIF-2C 2|eIF2C 2|eukaryotic translation initiation factor 2C, 2|hAgo2|protein argonaute-2|protein slicer
Swissprots Q8WV58 Q96ID1 Q8TCZ5 Q9UKV8
Accessions CAK32193 EAW92207 EAW92208 Q9UKV8 AA909234 AF121255 AAF13034 AI468419 AK096164 AK130012 AL050151 AY077717 AAL76093 BC007633 AAH07633 BC018727 AAH18727 BC054491 BC065217 BC125213 AAI25214 BC125214 BC160104 AAI60104 BT007229 AAP35893 HG501752 XM_011516964 XP_011515266 XM_011516965 XP_011515267 XM_011516966 XP_011515268 XM_011516967 XP_011515269 XM_011516968 XP_011515270 NM_001164623 NP_001158095 NM_012154 NP_036286
Function Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t
Subcellular Location Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.

EIF2C2-Over-expression-Lysate - LY11465a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag EIF2C2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EIF2C2 gene

EIF2C2 293 Cell Lysate - 407475 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

Ago2/eIF2C2 Overexpression Lysate (Native) - NBL1-10183 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: Ago2/eIF2C2 Overexpression Lysate (Adult Normal) [NBL1-10183] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Ago2/eIF2C2.

EIF2C2 Over-expression Lysate Product - GWB-BE42C5 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Human AGO2 / Argonaute 2 / EIF2C2 Insect Cell Lysate (WB positive control) - 11079-H07BL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human AGO2 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb174922 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human EIF2C2 Knockdown Stable Cell Line - CSC-DC004805 from Creative biogene

Category Cell Line
Species Human
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