AGO2

Gene Symbol	AGO2
Entrez Gene	27161
Alt Symbol	EIF2C2, Q10
Species	Human
Gene Type	protein-coding
Description	argonaute RISC catalytic component 2
Other Description	CTA-204B4.6|PAZ Piwi domain protein|PPD|argonaute 2|argonaute2|eIF-2C 2|eIF2C 2|eukaryotic translation initiation factor 2C, 2|hAgo2|protein argonaute-2|protein slicer
Swissprots	Q8WV58 Q96ID1 Q8TCZ5 Q9UKV8
Accessions	CAK32193 EAW92207 EAW92208 Q9UKV8 AA909234 AF121255 AAF13034 AI468419 AK096164 AK130012 AL050151 AY077717 AAL76093 BC007633 AAH07633 BC018727 AAH18727 BC054491 BC065217 BC125213 AAI25214 BC125214 BC160104 AAI60104 BT007229 AAP35893 HG501752 XM_011516964 XP_011515266 XM_011516965 XP_011515267 XM_011516966 XP_011515268 XM_011516967 XP_011515269 XM_011516968 XP_011515270 NM_001164623 NP_001158095 NM_012154 NP_036286
Function	Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t
Subcellular Location	Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-EIF2C2-cDNA-Clone - DC02199 from Abgent, a WuXi AppTec company Prices $508.95 Sizes 10 µg Species Human Accession BC007633

EIF2C2 - MBS1270348 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC007633

EIF2C2 - MBS1275868 from MyBioSource Species Human Accession BC018727

Human EIF2C2 cDNA clone(NM_001164623.1) - CDFH005768 from Creative Biomart Species Human Accession NM_001164623.1

Human EIF2C2 ORF Clone(NM_001164623.1) - CDCR354788 from Creative Biomart Species Human Accession NM_001164623.1

Human EIF2C2 ORF Clone(NM_001164623.1) - CDCR354789 from Creative Biomart Species Human Accession NM_001164623.1

Human EIF2C2 ORF Clone(NM_001164623.1) - CDCL162111 from Creative Biomart Species Human Accession NM_001164623.1

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone in cloning vector - HG11079-M from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11079-NY from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid - HG11079-UT from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11079-ACG from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11079-NH from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11079-CH from Sino Biological Species Human

Human AGO2 / EIF2C2 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG11079-M-F from Sino Biological Species Human Accession NM_012154.2

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11079-NF from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11079-NM from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11079-CF from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11079-ANG from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11079-CM from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11079-ACR from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11079-ANR from Sino Biological Species Human

Human AGO2/Argonaute 2/EIF2C2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11079-CY from Sino Biological Species Human

AGO2/EIF2C2 - CL01097H01 from Elabscience Species Human Accession NM_001164623.1

AGO2/EIF2C2 - CL01097H02 from Elabscience Species Human Accession NM_012154.3

Human EIF2C2 ORF clone (NM_001164623.1) - CDCR025604 from Creative biogene Species Human

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