Gene Symbol | AGO2 |
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Entrez Gene | 27161 |
Alt Symbol | EIF2C2, Q10 |
Species | Human |
Gene Type | protein-coding |
Description | argonaute RISC catalytic component 2 |
Other Description | CTA-204B4.6|PAZ Piwi domain protein|PPD|argonaute 2|argonaute2|eIF-2C 2|eIF2C 2|eukaryotic translation initiation factor 2C, 2|hAgo2|protein argonaute-2|protein slicer |
Swissprots | Q8WV58 Q96ID1 Q8TCZ5 Q9UKV8 |
Accessions | CAK32193 EAW92207 EAW92208 Q9UKV8 AA909234 AF121255 AAF13034 AI468419 AK096164 AK130012 AL050151 AY077717 AAL76093 BC007633 AAH07633 BC018727 AAH18727 BC054491 BC065217 BC125213 AAI25214 BC125214 BC160104 AAI60104 BT007229 AAP35893 HG501752 XM_011516964 XP_011515266 XM_011516965 XP_011515267 XM_011516966 XP_011515268 XM_011516967 XP_011515269 XM_011516968 XP_011515270 NM_001164623 NP_001158095 NM_012154 NP_036286 |
Function | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t |
Subcellular Location | Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8. |
Argonaute 2 (C34C6) Rabbit mAb - 2897 from Cell Signaling Technology
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eIF2C (B-3) - sc-376696 from Santa Cruz Biotechnology
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eIF2C (H-300) - sc-32877 from Santa Cruz Biotechnology
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eIF2C (N-16) - sc-32360 from Santa Cruz Biotechnology
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eIF2C2 (4F9) - sc-53521 from Santa Cruz Biotechnology
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eIF2C2 (N-13) - sc-32659 from Santa Cruz Biotechnology
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Anti-Ago2 / eIF2C2 antibody - ab135025 from Abcam
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Anti-Ago2 / eIF2C2 antibody [EPR10410] - ab156870 from Abcam
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Anti-Ago2 / eIF2C2 antibody [EPR10410] (Alexa Fluor® 488) - ab196469 from Abcam
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Anti-Ago2 / eIF2C2 antibody [EPR10410] (Alexa Fluor® 647) - ab196516 from Abcam
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Anti-Ago2 / eIF2C2 antibody [EPR10410] (HRP) - ab195892 from Abcam
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Anti-Ago2 / eIF2C2 antibody [EPR10411] - ab186733 from Abcam
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Anti-Ago2 / eIF2C2 antibody - ChIP Grade - ab32381 from Abcam
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Anti-Ago2 / eIF2C2 antibody - ChIP Grade - ab57113 from Abcam
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Anti-AGO2 / EIF2C2 Antibody (clone 2E12-1C9) IHC-plus⢠- LS-B6224 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody - LS-C69256 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody - LS-C128715 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody (N-Terminus, APC) - LS-C222370 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody (N-Terminus, Biotin) - LS-C222372 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody (N-Terminus, AP) - LS-C222371 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody (N-Terminus, FITC) - LS-C222373 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody (N-Terminus, Azide-free, HRP) - LS-C222374 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody (N-Terminus, PE) - LS-C222375 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody (aa498-812) - LS-C311886 from LifeSpan Bioscience
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Anti-AGO2 / EIF2C2 Antibody (N-Terminus) - LS-C329490 from LifeSpan Bioscience
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