| Gene Symbol |
ITGA5
|
| Entrez Gene |
3678
|
| Alt Symbol |
CD49e, FNRA, VLA-5, VLA5A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
|
| Other Description |
CD49 antigen-like family member E|fibronectin receptor subunit alpha|fibronectin receptor, alpha subunit|integrin alpha-5|integrin alpha-F|very late activation protein 5, alpha subunit
|
| Swissprots |
P08648 Q96HA5
|
| Accessions |
CBX47565 EAW96780 EAW96781 EAW96782 P08648 AK291570 BAF84259 AK304696 BAG65466 AK311051 AK312414 BAG35324 AU133210 AY429549 BC008786 AAH08786 BM787112 BX647780 DQ892690 ABM83616 EU176722 ABW03523 M13918 AAA52467 X06256 CAA29601 NM_002205 NP_002196
|
| Function |
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Proteoglycans in cancer, PI3K-Akt signaling pathway, MicroRNAs in cancer, Pertussis, Focal adhesion
|