Gene Symbol | ITGA5 |
---|---|
Entrez Gene | 3678 |
Alt Symbol | CD49e, FNRA, VLA-5, VLA5A |
Species | Human |
Gene Type | protein-coding |
Description | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Other Description | CD49 antigen-like family member E|fibronectin receptor subunit alpha|fibronectin receptor, alpha subunit|integrin alpha-5|integrin alpha-F|very late activation protein 5, alpha subunit |
Swissprots | P08648 Q96HA5 |
Accessions | CBX47565 EAW96780 EAW96781 EAW96782 P08648 AK291570 BAF84259 AK304696 BAG65466 AK311051 AK312414 BAG35324 AU133210 AY429549 BC008786 AAH08786 BM787112 BX647780 DQ892690 ABM83616 EU176722 ABW03523 M13918 AAA52467 X06256 CAA29601 NM_002205 NP_002196 |
Function | Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Proteoglycans in cancer, PI3K-Akt signaling pathway, MicroRNAs in cancer, Pertussis, Focal adhesion |