ITGA5

Gene Symbol ITGA5
Entrez Gene 3678
Alt Symbol CD49e, FNRA, VLA-5, VLA5A
Species Human
Gene Type protein-coding
Description integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Other Description CD49 antigen-like family member E|fibronectin receptor subunit alpha|fibronectin receptor, alpha subunit|integrin alpha-5|integrin alpha-F|very late activation protein 5, alpha subunit
Swissprots P08648 Q96HA5
Accessions CBX47565 EAW96780 EAW96781 EAW96782 P08648 AK291570 BAF84259 AK304696 BAG65466 AK311051 AK312414 BAG35324 AU133210 AY429549 BC008786 AAH08786 BM787112 BX647780 DQ892690 ABM83616 EU176722 ABW03523 M13918 AAA52467 X06256 CAA29601 NM_002205 NP_002196
Function Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Subcellular Location Membrane; Single-pass type I membrane protein.
Top Pathways Proteoglycans in cancer, PI3K-Akt signaling pathway, MicroRNAs in cancer, Pertussis, Focal adhesion

Integrin α5 Antibody - 4705 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A549, NIH/3T3 and COS cell lines using Integrin α5 Antibody.

Integrin α5 (H-104) - sc-10729 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Integrin α5 (H-104): sc-10729. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing membrane and cytoplasmic staining of decidual and trophoblastic cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Integrin α5 (P-19) - sc-6595 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin α5 (P-19): sc-6595. Western blot analysis of Integrin α5 expression in HeLa (A) and IL-6-treated HeLa (B) whole cell lysates.

Integrin α5 (C-9) - sc-376199 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α5 (C-9): sc-376199. Western blot analysis of Integrin α5 expression in non-transfected: sc-117752 (A) and human Integrin α5 transfected: sc-158642 (B) 293T whole cell lysates.0

Integrin α5 (A-11) - sc-166665 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α5 (A-11): sc-166665. Western blot analysis of Integrin α5 expression in non-transfected: sc-117752 (A) and human Integrin α5 transfected: sc-173627 (B) 293T whole cell lysates.

Integrin α5 (B-4) - sc-166681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α5 (B-4): sc-166681. Western blot analysis of Integrin α5 expression in non-transfected: sc-117752 (A) and human Integrin α5 transfected: sc-173627 (B) 293T whole cell lysates.

Integrin α5 (D-9) - sc-166666 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α5 (D-9): sc-166666. Western blot analysis of Integrin α5 expression in non-transfected: sc-117752 (A) and human Integrin α5 transfected: sc-173627 (B) 293T whole cell lysates.

Integrin α5 (P1D6) - sc-13547 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α5 (P1D6) PE: sc-13547 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>3</sub>: sc-2869.

Integrin α5 (JBS5) - sc-59762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α5 (JBS5): sc-59762. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin α5 (JBS5), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877

Integrin α5 (SAM-1) - sc-52595 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin α5 (1) - sc-136224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Integrin α5 (1): sc-136224. Western blot analysis of Integrin α5 expression in HeLa whole cell lysate.

Anti-CD49e antibody [CB49e] - ab106770 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CB49e

Anti-CD49e antibody [CB49e], prediluted (FITC) - ab106804 from Abcam

Prices $165.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone CB49e

Anti-CD49e antibody [CB49e], prediluted (PerCP) - ab106776 from Abcam

Prices $216.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone CB49e

Anti-Integrin alpha 5 + beta 1 antibody [P1D6] - ab75472 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone P1D6

Anti-Integrin alpha 5 antibody - ab112183 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin alpha 5 antibody (ab112183) at 1 µg/mlLane 1 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lane 2 : JEG-3 (Human placental choriocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Integrin alpha 5 antibody - ab200714 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin alpha 5 antibody (ab200714) at 1/500 dilutionLane 1 : HEK293T whole cell lysateLane 2 : Raw 264.7 whole cell lysateLane 3 : PC12 whole cell lysate

Anti-Integrin alpha 5 antibody - ab72663 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin alpha 5 antibody (ab72663) at 1/500 dilutionLane 1 : Extracts from 3T3 cells, treated with etoposide (25uM, 24hours)Lane 2 : Extracts from 3T3 cells, treated with etoposide (25uM, 24hours) with Cl-peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Integrin alpha 5 antibody - ab72665 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin alpha 5 antibody (ab72665) at 1/500 dilutionLane 1 : Extracts from 293 cells treated with etoposide (25uM, 1hour)Lane 2 : Extracts from A549 cells treated with etoposide (25uM, 1hour)Lane 3 : Extracts from 293 cells treated with etoposide (25uM, 1hour) with Cl-peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Integrin alpha 5 antibody - ab130968 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Integrin alpha 5 antibody (ab130968) at 1 µg/ml + MDA-MB-435S cell lysate at 10 µgSecondaryGoat anti-Rabbit IgG HRP

Anti-Integrin alpha 5 antibody [10F6] - ab93943 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10F6
Anti-Integrin alpha 5 antibody [10F6] (ab93943) at 1/500 dilution + Integrin alpha 5-hIgGFc transfected HEK293 cell lysate.

Anti-Integrin alpha 5 antibody [EPR7854] - ab150361 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7854
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized U937 (Human histiocytic lymphoma) cells labeling Integrin alpha 5 with ab150361 at 1/500 dilution, followed by Goat anti-rabbit IgG (Alexa Fluor 488) (ab150077) secondary antibody at 1/400 dilution (green). Confocal image showing mainly membrane staining on U937 cell line. The nuclear counterstain is DAPI (blue).

Anti-Integrin alpha 5 antibody [JBS5] - ab23589 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JBS5

Anti-Integrin alpha 5 antibody [NKI-SAM1] - ab36769 from Abcam

Prices $372.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone NKI-SAM1

Anti-Integrin alpha 5 antibody [P1D6] - ab78614 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone P1D6
Overlay histogram showing HeLa cells stained with ab78614 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine (ab120050) to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab78614, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG3 [MG3-35] (ab18394, 1µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive result in 4% paraformaldehyde (10 min) fixed HeLa cells used under the same conditions.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.
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