| Gene Symbol |
MARCH2
|
| Entrez Gene |
51257
|
| Alt Symbol |
HSPC240, MARCH-II, RNF172
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase MARCH2|RING finger protein 172|membrane-associated RING finger protein 2|membrane-associated RING-CH protein II
|
| Swissprots |
Q5H785 Q96B78 Q8N5A3 A6NP10 Q9P0N8
|
| Accessions |
EAW68924 Q9P0N8 AB197929 BAD89359 AF151074 AAF36160 AK130163 BC015910 AAH15910 BC032624 AAH32624 BC111388 AAI11389 BI546028 CN363445 DQ582066 XM_006722763 XP_006722826 XM_011528046 XP_011526348 XM_011528047 XP_011526349 NM_001005415 NP_001005415 NM_001005416 NP_001005416 NM_016496 NP_057580
|
| Function |
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:15689499, ECO:0000269|PubMed:16428329}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}. Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Broadly expressed. {ECO:0000269|PubMed:14722266}.
|