MARCH2

Gene Symbol	MARCH2
Entrez Gene	51257
Alt Symbol	HSPC240, MARCH-II, RNF172
Species	Human
Gene Type	protein-coding
Description	membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MARCH2|RING finger protein 172|membrane-associated RING finger protein 2|membrane-associated RING-CH protein II
Swissprots	Q5H785 Q96B78 Q8N5A3 A6NP10 Q9P0N8
Accessions	EAW68924 Q9P0N8 AB197929 BAD89359 AF151074 AAF36160 AK130163 BC015910 AAH15910 BC032624 AAH32624 BC111388 AAI11389 BI546028 CN363445 DQ582066 XM_006722763 XP_006722826 XM_011528046 XP_011526348 XM_011528047 XP_011526349 NM_001005415 NP_001005415 NM_001005416 NP_001005416 NM_016496 NP_057580
Function	E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:15689499, ECO:0000269|PubMed:16428329}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}. Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	Broadly expressed. {ECO:0000269|PubMed:14722266}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MARCH2 full length protein - ab162472 from Abcam Category Protein Source Wheat germ Species Human

Human MARCH2 protein fragment - ab162473 from Abcam Category Protein Source Wheat germ Species Human

MARCH2 Antibody Blocking Peptide - LS-E26516 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MARCH2 Protein - H00051257-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MARCH2 Partial Recombinant Protein - H00051257-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MARCH2/MARCH-II blocking peptide - GTX88914-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

RNF172 Blocking Peptide - 33R-9112 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MARCH2 Peptide - AC21-1352-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MARCH2 / RNF172 - H00051257-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MARCH2 / RNF172 - H00051257-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MARCH2 / RNF172 - H00051257-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MARCH2 / RNF172 - H00051257-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MARCH II Peptide - 45-865P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

MARCH2 fusion protein - Ag4318 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human 41335, GST-tagged - MARCH2-745H from Creative Biomart Category Protein Source E.coli Species Human

MARCH2 / RNF172 (transcript variant 1) - TP307517 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MARCH2 / RNF172 (transcript variant 2) - TP318593 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MARCH2/MARCH-II, Peptide - MBS425476 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

MARCH2 Protein - NBP1-91638PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

MARCH2 Recombinant Protein Antigen - NBP1-82168PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MOSC2 Recombinant Protein Antigen - NBP1-82167PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MARCH2 Peptide, Human - M34GP09224H from Creative Peptides Category Peptide Source Synthetic. Species Human

MARCH2 Blocking Peptide - CBP5334 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Rat

human MARCH2 protein - orb54679 from Biorbyt Category Protein Prices $1,598.00, $3,094.00, $4,964.00 Sizes 10 μg, 50 μg, 100 μg Species Human

E3 ubiquitin-protein ligase MARCH2 (MARCH2), Recombinant Protein - MBS7006863 from MyBioSource Category Protein Prices $1,060.00, $2,045.00, $3,255.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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