MARCH2

Gene Symbol MARCH2
Entrez Gene 51257
Alt Symbol HSPC240, MARCH-II, RNF172
Species Human
Gene Type protein-coding
Description membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase MARCH2|RING finger protein 172|membrane-associated RING finger protein 2|membrane-associated RING-CH protein II
Swissprots Q5H785 Q96B78 Q8N5A3 A6NP10 Q9P0N8
Accessions EAW68924 Q9P0N8 AB197929 BAD89359 AF151074 AAF36160 AK130163 BC015910 AAH15910 BC032624 AAH32624 BC111388 AAI11389 BI546028 CN363445 DQ582066 XM_006722763 XP_006722826 XM_011528046 XP_011526348 XM_011528047 XP_011526349 NM_001005415 NP_001005415 NM_001005416 NP_001005416 NM_016496 NP_057580
Function E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:15689499, ECO:0000269|PubMed:16428329}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}. Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Broadly expressed. {ECO:0000269|PubMed:14722266}.

Human MARCH2 cDNA clone(NM_016496.4) - CDFG000455 from Creative Biomart

Species Human
Accession NM_016496.4

Human MARCH2 cDNA clone(NM_001005415.1) - CDFH011079 from Creative Biomart

Species Human
Accession NM_001005415.1

Human MARCH2 cDNA clone(NM_001005416.1) - CDFH011080 from Creative Biomart

Species Human
Accession NM_001005416.1

Human MARCH2 ORF Clone(NM_016496.4) - CDCR301318 from Creative Biomart

Species Human
Accession NM_016496.4

Human MARCH2 ORF Clone(NM_016496.4) - CDCR301319 from Creative Biomart

Species Human
Accession NM_016496.4

Human MARCH2 ORF Clone(NM_001005415.1) - CDCR339726 from Creative Biomart

Species Human
Accession NM_001005415.1

Human MARCH2 ORF Clone(NM_001005415.1) - CDCR339727 from Creative Biomart

Species Human
Accession NM_001005415.1

Human MARCH2 ORF Clone(NM_001005415.1) - CDCR339728 from Creative Biomart

Species Human
Accession NM_001005415.1

Human MARCH2 ORF Clone(NM_001005416.1) - CDCR339729 from Creative Biomart

Species Human
Accession NM_001005416.1

Human MARCH2 ORF Clone(NM_001005416.1) - CDCR339730 from Creative Biomart

Species Human
Accession NM_001005416.1

Human MARCH2 ORF Clone(NM_001005416.1) - CDCR339731 from Creative Biomart

Species Human
Accession NM_001005416.1

Human MARCH2 ORF Clone(NM_016496.4) - CDCR301318 from Creative biogene

Species Human

Human MARCH2 ORF Clone(NM_001005415.1) - CDCR339726 from Creative biogene

Species Human

Human MARCH2 ORF clone (NM_001005416.1) - CDCR038964 from Creative biogene

Species Human

Human MARCH2 ORF Clone (BC111388) - CDCS414309 from Creative biogene

Species Human
Accession Q9P0N8

Human MARCH2 cDNA Clone(NM_016496.4) - CDFG000455 from Creative biogene

Species Human

Human MARCH2 cDNA Clone(NM_001005415.1) - CDFH011079 from Creative biogene

Species Human

Human MARCH2 cDNA Clone(NM_001005416.1) - CDFH011080 from Creative biogene

Species Human
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