| Gene Symbol |
MED17
|
| Entrez Gene |
9440
|
| Alt Symbol |
CRSP6, CRSP77, DRIP80, TRAP80
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 17
|
| Other Description |
ARC77|CRSP complex subunit 6|activator-recruited cofactor 77 kDa component|cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa|mediator of RNA polymerase II transcription subunit 17|thyroid hormone receptor-associated protein complex 80 kDa component|transcriptional coactivator CRSP77|vitamin D3 receptor-interacting protein complex 80 kDa component
|
| Swissprots |
Q9HA81 B3KN07 Q9Y660 Q9NVC6 Q9UNP7 Q9Y2W0
|
| Accessions |
EAW66920 EAW66921 Q9NVC6 AF104254 AAD12723 AF105421 AAD30856 AF117657 AAD22031 AK001674 BAA91827 AK022156 BAB13973 AK023209 BAG51169 AK299702 BAG61603 BC021101 AAH21101 DA506467 DA921529 XM_011543068 XP_011541370 XR_247218 XR_947872 NM_004268 NP_004259
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10198638}.
|
![Western Blot: MED17 Overexpression Lysate (Adult Normal) [NBL1-12982] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MED17.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2059_MED17%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12982-img0002.jpg)