Gene Symbol | MED17 |
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Entrez Gene | 9440 |
Alt Symbol | CRSP6, CRSP77, DRIP80, TRAP80 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 17 |
Other Description | ARC77|CRSP complex subunit 6|activator-recruited cofactor 77 kDa component|cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa|mediator of RNA polymerase II transcription subunit 17|thyroid hormone receptor-associated protein complex 80 kDa component|transcriptional coactivator CRSP77|vitamin D3 receptor-interacting protein complex 80 kDa component |
Swissprots | Q9HA81 B3KN07 Q9Y660 Q9NVC6 Q9UNP7 Q9Y2W0 |
Accessions | EAW66920 EAW66921 Q9NVC6 AF104254 AAD12723 AF105421 AAD30856 AF117657 AAD22031 AK001674 BAA91827 AK022156 BAB13973 AK023209 BAG51169 AK299702 BAG61603 BC021101 AAH21101 DA506467 DA921529 XM_011543068 XP_011541370 XR_247218 XR_947872 NM_004268 NP_004259 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10198638}. |
CRSP77 CRISPR/Cas9 KO Plasmid (h) - sc-402693 from Santa Cruz Biotechnology
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CRSP77 HDR Plasmid (h) - sc-402693-HDR from Santa Cruz Biotechnology
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CRSP77 Double Nickase Plasmid (h) - sc-402693-NIC from Santa Cruz Biotechnology
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CRSP77 Double Nickase Plasmid (h2) - sc-402693-NIC-2 from Santa Cruz Biotechnology
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CRSP77 CRISPR Activation Plasmid (h) - sc-402693-ACT from Santa Cruz Biotechnology
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CRSP77 CRISPR Activation Plasmid (h2) - sc-402693-ACT-2 from Santa Cruz Biotechnology
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CRSP77 Lentiviral Activation Particles (h) - sc-402693-LAC from Santa Cruz Biotechnology
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CRSP77 Lentiviral Activation Particles (h2) - sc-402693-LAC-2 from Santa Cruz Biotechnology
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CRSP77 siRNA (h) - sc-38575 from Santa Cruz Biotechnology
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CRSP77 shRNA Plasmid (h) - sc-38575-SH from Santa Cruz Biotechnology
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CRSP77 shRNA (h) Lentiviral Particles - sc-38575-V from Santa Cruz Biotechnology
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MED17 RNAi - H00009440-R01 from Novus Biologicals
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MISSION® esiRNA - EHU130521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13166 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13166 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08753 from Sigma-Aldrich
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MED17 siRNA (Human) - CRH6259 from Cohesion Biosciences
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shRNA set against Human CRSP6(NM_004268.4) - SHH000793 from Creative biogene
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MED17 shRNA Plasmid (Human) - CHH6259 from Cohesion Biosciences
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MED17 miRNA 3'UTR clone - MiUTR1H-02439 from Creative biogene
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