| Gene Symbol | MED17 |
|---|---|
| Entrez Gene | 9440 |
| Alt Symbol | CRSP6, CRSP77, DRIP80, TRAP80 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mediator complex subunit 17 |
| Other Description | ARC77|CRSP complex subunit 6|activator-recruited cofactor 77 kDa component|cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa|mediator of RNA polymerase II transcription subunit 17|thyroid hormone receptor-associated protein complex 80 kDa component|transcriptional coactivator CRSP77|vitamin D3 receptor-interacting protein complex 80 kDa component |
| Swissprots | Q9HA81 B3KN07 Q9Y660 Q9NVC6 Q9UNP7 Q9Y2W0 |
| Accessions | EAW66920 EAW66921 Q9NVC6 AF104254 AAD12723 AF105421 AAD30856 AF117657 AAD22031 AK001674 BAA91827 AK022156 BAB13973 AK023209 BAG51169 AK299702 BAG61603 BC021101 AAH21101 DA506467 DA921529 XM_011543068 XP_011541370 XR_247218 XR_947872 NM_004268 NP_004259 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10198638}. |