| Gene Symbol |
PRKAB1
|
| Entrez Gene |
5564
|
| Alt Symbol |
AMPK, HAMPKb
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, AMP-activated, beta 1 non-catalytic subunit
|
| Other Description |
5'-AMP-activated protein kinase beta-1 subunit|5'-AMP-activated protein kinase subunit beta-1|AMP-activated protein kinase beta subunit|AMPK beta -1 chain|AMPK beta 1|AMPK subunit beta-1|AMPKb|protein kinase, AMP-activated, noncatalytic, beta-1
|
| Swissprots |
Q9Y478 Q9UE20 Q9UEX2 Q9Y6V8 Q9UBV0
|
| Accessions |
AAB71326 AAD00625 EAW98151 EAW98152 EAW98153 EAW98154 Q9Y478 AF022116 AAC98897 AJ224515 CAA12024 AK127820 AK301165 BAG62754 AK312495 BAG35397 BC001007 AAH01007 BC001056 AAH01056 BC001823 AAH01823 BC017671 AAH17671 BC018818 BU539177 BX537486 U83994 AAD09237 Y12556 CAA73146 XM_005253909 XP_005253966 NM_006253 NP_006244
|
| Function |
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
|
| Top Pathways |
Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm
|