| Gene Symbol |
DDIT3
|
| Entrez Gene |
1649
|
| Alt Symbol |
CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA-damage-inducible transcript 3
|
| Other Description |
C/EBP zeta|CCAAT/enhancer-binding protein homologous protein|DDIT-3|DNA damage-inducible transcript 3 protein|c/EBP-homologous protein 10|growth arrest and DNA damage-inducible protein GADD153
|
| Swissprots |
F8VS99 P35638
|
| Accessions |
AAW56077 EAW97021 EAW97022 EAW97023 P35638 AA054097 AA476561 AI658803 AK316581 BAG38169 AV729744 AY461580 BC003637 AAH03637 BC064556 BC107859 BM464290 BT006691 AAP35337 BU664077 CN482428 EU831488 ACE87175 EU831575 ACE86494 S40706 AAB22646 XM_011538006 XP_011536308 NM_001195053 NP_001181982 NM_001195054 NP_001181983 NM_001195055 NP_001181984 NM_001195056 NP_001181985 NM_001195057 NP_001181986 NM_004083 NP_004074
|
| Function |
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the c
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
|
| Top Pathways |
MAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer
|
![Western Blot: CHOP/GADD153 Overexpression Lysate (Adult Normal) [NBL1-09772] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHOP/GADD153.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1033_CHOP-GADD153%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09772-img0002.jpg)