DDIT3

Gene Symbol	DDIT3
Entrez Gene	1649
Alt Symbol	CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
Species	Human
Gene Type	protein-coding
Description	DNA-damage-inducible transcript 3
Other Description	C/EBP zeta|CCAAT/enhancer-binding protein homologous protein|DDIT-3|DNA damage-inducible transcript 3 protein|c/EBP-homologous protein 10|growth arrest and DNA damage-inducible protein GADD153
Swissprots	F8VS99 P35638
Accessions	AAW56077 EAW97021 EAW97022 EAW97023 P35638 AA054097 AA476561 AI658803 AK316581 BAG38169 AV729744 AY461580 BC003637 AAH03637 BC064556 BC107859 BM464290 BT006691 AAP35337 BU664077 CN482428 EU831488 ACE87175 EU831575 ACE86494 S40706 AAB22646 XM_011538006 XP_011536308 NM_001195053 NP_001181982 NM_001195054 NP_001181983 NM_001195055 NP_001181984 NM_001195056 NP_001181985 NM_001195057 NP_001181986 NM_004083 NP_004074
Function	Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the c
Subcellular Location	Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Top Pathways	MAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDIT3 full length protein - ab134889 from Abcam Category Protein Source E. coli Species Human

Human DDIT3 full length protein - ab74521 from Abcam Category Protein Source E. coli Species Human

Human DDIT3 full length protein - ab117195 from Abcam Category Protein Source E. coli Species Human

CEBPZ / CBF Antibody Blocking Peptide - LS-E10790 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEBPZ / CBF Antibody Blocking Peptide - LS-E7047 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEBPZ / CBF Antibody Blocking Peptide - LS-E13924 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEBPZ / CBF Antibody Blocking Peptide - LS-E28000 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CEBPZ / CBF Antibody Blocking Peptide - LS-E28001 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDIT3 / CHOP Antibody Blocking Peptide - LS-E1325 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDIT3 / CHOP Antibody Blocking Peptide - LS-E2155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GADD153/CHOP Blocking Peptide - NBP2-13172PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

CHOP/GADD153 Partial Recombinant Protein - H00001649-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GADD153/CHOP Recombinant Protein - H00001649-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GADD153/CHOP Partial Recombinant Protein - H00001649-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human GADD153/CHOP Protein - NBC1-18430 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

GADD153/CHOP Peptide - NB100-91777PEP from Novus Biologicals Category Peptide Prices $179.00 Sizes 100 µg

CBF2 Peptide - P1214 from Novus Biologicals Category Peptide Species Human

DDIT3-Antibody-C-term-A135-Blocking-peptide - BP11955b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDIT3-Antibody-Center-Blocking-peptide - BP13063c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GADD153 Protein - GTX112827-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

DDIT3 Protein (OPPA01740) - OPPA01740 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human DDIT3 protein - orb81066 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

DDIT3 peptide - orb217198 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

DDIT3 peptide - orb219064 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Monkey, Pig

CEBPZ Blocking Peptide - 33R-4297 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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