| Gene Symbol | DDIT3 |
|---|---|
| Entrez Gene | 1649 |
| Alt Symbol | CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 |
| Species | Human |
| Gene Type | protein-coding |
| Description | DNA-damage-inducible transcript 3 |
| Other Description | C/EBP zeta|CCAAT/enhancer-binding protein homologous protein|DDIT-3|DNA damage-inducible transcript 3 protein|c/EBP-homologous protein 10|growth arrest and DNA damage-inducible protein GADD153 |
| Swissprots | F8VS99 P35638 |
| Accessions | AAW56077 EAW97021 EAW97022 EAW97023 P35638 AA054097 AA476561 AI658803 AK316581 BAG38169 AV729744 AY461580 BC003637 AAH03637 BC064556 BC107859 BM464290 BT006691 AAP35337 BU664077 CN482428 EU831488 ACE87175 EU831575 ACE86494 S40706 AAB22646 XM_011538006 XP_011536308 NM_001195053 NP_001181982 NM_001195054 NP_001181983 NM_001195055 NP_001181984 NM_001195056 NP_001181985 NM_001195057 NP_001181986 NM_004083 NP_004074 |
| Function | Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the c |
| Subcellular Location | Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. |
| Top Pathways | MAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer |