| Gene Symbol |
CYP4F11
|
| Entrez Gene |
57834
|
| Alt Symbol |
CYPIVF11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 4, subfamily F, polypeptide 11
|
| Other Description |
3-hydroxy fatty acids omega-hydroxylase CYP4F11|cytochrome P450 4F11|cytochrome P450, subfamily IVF, polypeptide 11|phylloquinone omega-hydroxylase CYP4F11
|
| Swissprots |
Q96AQ5 A8K059 A0A024R7G0 Q9HBI6 O75254
|
| Accessions |
AAC27731 EAW84511 EAW84512 EAW84513 EAW84514 EAW84515 Q9HBI6 AF236085 AAG15889 AK125714 AK289424 BAF82113 AK309292 AL833940 CAD38795 BC016853 AAH16853 BM727421 BU180723 DC345817 DQ891467 ABM82393 DQ894650 ABM85576 XM_011528156 XP_011526458 NM_001128932 NP_001122404 NM_021187 NP_067010
|
| Function |
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3- hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545). {ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:19932081, ECO:0000269|PubMed:24138531}.
|
| Subcellular Location |
Microsome membrane {ECO:0000269|PubMed:18065749}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle. {ECO:0000269|PubMed:10964514, ECO:0000269|PubMed:24138531}.
|