| Gene Symbol |
MCMBP
|
| Entrez Gene |
79892
|
| Alt Symbol |
C10orf119, MCM-BP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex binding protein
|
| Other Description |
MCM-binding protein|mini-chromosome maintenance complex-binding protein|minichromosome maintenance complex-binding protein
|
| Swissprots |
Q9H916 Q9BTE3 Q9BVT9 B3KSP7 Q6IA56
|
| Accessions |
EAW49375 EAW49376 EAW49377 EAW49378 Q9BTE3 AA292620 AK001928 AK023143 BAB14427 AK094075 BAG52809 BC000935 AAH00935 BC004183 AAH04183 BC007219 AAH07219 BQ929053 CN259319 CR457299 CAG33580 DA381502 XM_005270157 XP_005270214 XM_011540170 XP_011538472 NM_001256378 NP_001243307 NM_001256379 NP_001243308 NM_024834 NP_079110
|
| Function |
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17296731}. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
|