RLIM

Gene Symbol RLIM
Entrez Gene 51132
Alt Symbol NY-REN-43, RNF12
Species Human
Gene Type protein-coding
Description ring finger protein, LIM domain interacting
Other Description E3 ubiquitin-protein ligase RLIM|E3 ubiquitin-protein ligase RNF12|LIM domain-interacting RING finger protein|R-LIM|RING finger LIM domain-binding protein|renal carcinoma antigen NY-REN-43|ring finger protein 12|ring zinc finger LIM domain binding protein|ring zinc finger protein NY-REN-43antigen
Swissprots D3DTE0 Q96D38 B2RBQ1 Q9NVW2 Q9Y598
Accessions CAC14228 EAW98639 EAW98640 Q9NVW2 AF086467 AF155109 AAD42875 AI968256 AK001334 BAA91632 AK098789 AK123088 AK124877 AK127880 AK314760 BAG37298 AL712605 BC013357 AAH13357 BF686000 BG259627 BX648613 DQ893500 ABM84426 DQ896498 ABM87497 NM_016120 NP_057204 NM_183353 NP_899196
Function E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}.
Subcellular Location Nucleus {ECO:0000269|PubMed:19117995, ECO:0000269|PubMed:19164295}.
Tissue Specificity Expressed in many tissues.

RLIM (N-20) - sc-55391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RLIM (N-20): sc-55391. Western blot analysis of RLIM expression in IMR-32 nuclear extract (A) and Jurkat whole cell lysate (B).

RLIM (SK-46) - sc-101117 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
RLIM (SK-46): sc-101117. Western blot analysis of RLIM expression in HeLa nuclear extract.

Anti-RNF12 antibody - ab22813 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab22813 used at 4-8 µg/ml on parffin embeded tissue: Human spermatophore cells with positive label: Epithelial cells (indicated with arrows)

Anti-RNF12 antibody - ab156245 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RNF12 antibody (ab156245) at 1/100 dilution + HL60 cell line lysate at 35 µg

Anti-RNF12 antibody - ab57230 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-RNF12 antibody - ab97838 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RNF12 antibody (ab97838) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysateSecondaryHRP-conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-RNF12 antibody - ab154215 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RNF12 antibody (ab154215) at 1/1000 dilutionLane 1 : Jurkat whole cell lysateLane 2 : Raji whole cell lysateLane 3 : K562 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-RNF12 antibody - ab172421 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-RNF12 antibody (ab172421) at 1 µg/mlLane 1 : RNF12 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-RLIM / RNF12 Antibody (aa199-227, AP) - LS-C240021 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RLIM / RNF12 Antibody (aa199-227, Biotin) - LS-C240023 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RLIM / RNF12 Antibody (aa199-227, PE) - LS-C240026 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RLIM / RNF12 Antibody (aa199-227, FITC) - LS-C240025 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RLIM / RNF12 Antibody (aa199-227, APC) - LS-C240024 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RLIM / RNF12 Antibody (aa199-227, Azide-free, HRP) - LS-C248006 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RLIM / RNF12 Antibody (aa1-84, Azide-free) - LS-C328553 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-RLIM / RNF12 Antibody (aa199-227) - LS-C324689 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RLIM / RNF12 Antibody (aa199-227) - LS-C155992 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RLIM Antibody western blot of HL-60 cell line lysates (35 ug/lane). The RLIM antibody detected the RLIM protein (arrow).

Anti-RLIM / RNF12 Antibody (N-Terminus) - LS-C107488 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RLIM / RNF12 antibody LS-C107488 Western blot of HT1080 cell lysate.

Anti-RLIM / RNF12 Antibody (aa532-581) - LS-C29679 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RLIM / RNF12 antibody LS-C29679 was used in IHC to stain formalin-fixed, paraffin-embedded human spermatophore.

RNF12 Antibody (1G10) - H00051132-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G10
Western Blot: RNF12 Antibody (1G10) [H00051132-M01] - RNF12 monoclonal antibody (M01), clone 1G10. Analysis of RNF12 expression in Hela S3 NE.

RNF12 Antibody - NBP1-89571 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: RNF12 Antibody [NBP1-89571] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm.

RNF12 Antibody - NBP2-20175 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RNF12 Antibody [NBP2-20175] - Sample (30 ug of whole cell lysate) A: Jurkat B: Raji C: K562 7. 5% SDS PAGE gel, diluted at 1:1000.

RNF12 Antibody - H00051132-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RNF12 Antibody [H00051132-B01P] - Analysis of RNF12 expression in transfected 293T cell line by RNF12 polyclonal antibody. Lane 1: RNF12 transfected lysate(68.64 KDa). Lane 2: Non-transfected lysate.

RNF12 Antibody - H00051132-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

RNF12 Antibody - H00051132-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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