RLIM

Gene Symbol RLIM
Entrez Gene 51132
Alt Symbol NY-REN-43, RNF12
Species Human
Gene Type protein-coding
Description ring finger protein, LIM domain interacting
Other Description E3 ubiquitin-protein ligase RLIM|E3 ubiquitin-protein ligase RNF12|LIM domain-interacting RING finger protein|R-LIM|RING finger LIM domain-binding protein|renal carcinoma antigen NY-REN-43|ring finger protein 12|ring zinc finger LIM domain binding protein|ring zinc finger protein NY-REN-43antigen
Swissprots D3DTE0 Q96D38 B2RBQ1 Q9NVW2 Q9Y598
Accessions CAC14228 EAW98639 EAW98640 Q9NVW2 AF086467 AF155109 AAD42875 AI968256 AK001334 BAA91632 AK098789 AK123088 AK124877 AK127880 AK314760 BAG37298 AL712605 BC013357 AAH13357 BF686000 BG259627 BX648613 DQ893500 ABM84426 DQ896498 ABM87497 NM_016120 NP_057204 NM_183353 NP_899196
Function E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}.
Subcellular Location Nucleus {ECO:0000269|PubMed:19117995, ECO:0000269|PubMed:19164295}.
Tissue Specificity Expressed in many tissues.

RNF12 293T Cell Transient Overexpression Lysate(Denatured) - H00051132-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

RNF12 Overexpression Lysate (Denatured) - H00051132-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

RNF12 Overexpression Lysate (Denatured) - H00051132-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human RLIM Knockdown Stable Cell Line - CSC-DC013332 from Creative biogene

Category Cell Line
Species Human
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