| Gene Symbol |
RLIM
|
| Entrez Gene |
51132
|
| Alt Symbol |
NY-REN-43, RNF12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein, LIM domain interacting
|
| Other Description |
E3 ubiquitin-protein ligase RLIM|E3 ubiquitin-protein ligase RNF12|LIM domain-interacting RING finger protein|R-LIM|RING finger LIM domain-binding protein|renal carcinoma antigen NY-REN-43|ring finger protein 12|ring zinc finger LIM domain binding protein|ring zinc finger protein NY-REN-43antigen
|
| Swissprots |
D3DTE0 Q96D38 B2RBQ1 Q9NVW2 Q9Y598
|
| Accessions |
CAC14228 EAW98639 EAW98640 Q9NVW2 AF086467 AF155109 AAD42875 AI968256 AK001334 BAA91632 AK098789 AK123088 AK124877 AK127880 AK314760 BAG37298 AL712605 BC013357 AAH13357 BF686000 BG259627 BX648613 DQ893500 ABM84426 DQ896498 ABM87497 NM_016120 NP_057204 NM_183353 NP_899196
|
| Function |
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19117995, ECO:0000269|PubMed:19164295}.
|
| Tissue Specificity |
Expressed in many tissues.
|