RLIM

Gene Symbol	RLIM
Entrez Gene	51132
Alt Symbol	NY-REN-43, RNF12
Species	Human
Gene Type	protein-coding
Description	ring finger protein, LIM domain interacting
Other Description	E3 ubiquitin-protein ligase RLIM|E3 ubiquitin-protein ligase RNF12|LIM domain-interacting RING finger protein|R-LIM|RING finger LIM domain-binding protein|renal carcinoma antigen NY-REN-43|ring finger protein 12|ring zinc finger LIM domain binding protein|ring zinc finger protein NY-REN-43antigen
Swissprots	D3DTE0 Q96D38 B2RBQ1 Q9NVW2 Q9Y598
Accessions	CAC14228 EAW98639 EAW98640 Q9NVW2 AF086467 AF155109 AAD42875 AI968256 AK001334 BAA91632 AK098789 AK123088 AK124877 AK127880 AK314760 BAG37298 AL712605 BC013357 AAH13357 BF686000 BG259627 BX648613 DQ893500 ABM84426 DQ896498 ABM87497 NM_016120 NP_057204 NM_183353 NP_899196
Function	E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19117995, ECO:0000269|PubMed:19164295}.
Tissue Specificity	Expressed in many tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF12 full length protein - ab162428 from Abcam Category Protein Source Wheat germ Species Human

Human RNF12 protein fragment - ab162429 from Abcam Category Protein Source Wheat germ Species Human

RLIM / RNF12 Antibody Blocking Peptide - LS-E11236 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RLIM / RNF12 Antibody Blocking Peptide - LS-E11237 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF12 Protein - H00051132-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RNF12 Protein - H00051132-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF12 / RLIM - H00051132-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF12 / RLIM - H00051132-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF12 / RLIM - H00051132-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF12 / RLIM - H00051132-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RLIM fusion protein - Ag9077 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RLIM fusion protein - Ag9090 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human RLIM, GST-tagged - RLIM-2318H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase RLIM(RLIM) - CSB-YP873666HU CSB-EP873666HU CSB-BP873666HU CSB-MP873666HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF12 / RLIM (full length, N-term HIS tag, transcript variant 2) - TP760783 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

RNF12 Protein - NBP1-89571PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RLIM-Blocking-Peptide-Center - BP20050c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RLIM Peptide, Human - M34GP13332H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase RLIM (RLIM), Recombinant Protein - MBS1316770 from MyBioSource Category Protein Prices $1,420.00, $1,420.00, $1,645.00, $1,645.00, $2,400.00, $2,400.00, $2,845.00, $2,845.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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