RLIM
| Gene Symbol | RLIM |
|---|---|
| Entrez Gene | 51132 |
| Alt Symbol | NY-REN-43, RNF12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ring finger protein, LIM domain interacting |
| Other Description | E3 ubiquitin-protein ligase RLIM|E3 ubiquitin-protein ligase RNF12|LIM domain-interacting RING finger protein|R-LIM|RING finger LIM domain-binding protein|renal carcinoma antigen NY-REN-43|ring finger protein 12|ring zinc finger LIM domain binding protein|ring zinc finger protein NY-REN-43antigen |
| Swissprots | D3DTE0 Q96D38 B2RBQ1 Q9NVW2 Q9Y598 |
| Accessions | CAC14228 EAW98639 EAW98640 Q9NVW2 AF086467 AF155109 AAD42875 AI968256 AK001334 BAA91632 AK098789 AK123088 AK124877 AK127880 AK314760 BAG37298 AL712605 BC013357 AAH13357 BF686000 BG259627 BX648613 DQ893500 ABM84426 DQ896498 ABM87497 NM_016120 NP_057204 NM_183353 NP_899196 |
| Function | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19117995, ECO:0000269|PubMed:19164295}. |
| Tissue Specificity | Expressed in many tissues. |
RLIM CRISPR/Cas9 KO Plasmid (h) - sc-408088 from Santa Cruz Biotechnology
|
||||||||
RLIM HDR Plasmid (h) - sc-408088-HDR from Santa Cruz Biotechnology
|
||||||||
RLIM Double Nickase Plasmid (h) - sc-408088-NIC from Santa Cruz Biotechnology
|
||||||||
RLIM Double Nickase Plasmid (h2) - sc-408088-NIC-2 from Santa Cruz Biotechnology
|
||||||||
RLIM CRISPR Activation Plasmid (h) - sc-408088-ACT from Santa Cruz Biotechnology
|
||||||||
RLIM CRISPR Activation Plasmid (h2) - sc-408088-ACT-2 from Santa Cruz Biotechnology
|
||||||||
RLIM Lentiviral Activation Particles (h) - sc-408088-LAC from Santa Cruz Biotechnology
|
||||||||
RLIM Lentiviral Activation Particles (h2) - sc-408088-LAC-2 from Santa Cruz Biotechnology
|
||||||||
RLIM siRNA (h) - sc-62952 from Santa Cruz Biotechnology
|
||||||||
RLIM shRNA Plasmid (h) - sc-62952-SH from Santa Cruz Biotechnology
|
||||||||
RLIM shRNA (h) Lentiviral Particles - sc-62952-V from Santa Cruz Biotechnology
|
||||||||
RNF12 RNAi - H00051132-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU114371 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN18306 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18306 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR08901 from Sigma-Aldrich
|
||||||||
RLIM siRNA (Human) - CRH9551 from Cohesion Biosciences
|
||||||||
RNF12 RNAi - H00051132-R02 from Novus Biologicals
|
||||||||
RLIM - MBS8208406 from MyBioSource
|
||||||||
shRNA set against Human RLIM (NM_183353.2) - SHH396124 from Creative biogene
|
||||||||
Human RLIM siRNA - orb270053 from Biorbyt
|
||||||||
RLIM shRNA Plasmid (Human) - CHH9551 from Cohesion Biosciences
|