PRKCH

Gene Symbol PRKCH
Entrez Gene 5583
Alt Symbol PKC-L, PKCL, PRKCL, nPKC-eta
Species Human
Gene Type protein-coding
Description protein kinase C, eta
Other Description protein kinase C eta type
Swissprots P24723 Q8NE03 Q16246 B4DJN5
Accessions AAD12779 CAH05605 CBX47631 EAW80800 EAW80801 EAW80802 P24723 AB451313 BAG70127 AK093241 AK290183 BAF82872 AK296158 BAG58897 AK300864 BAG62513 AW008462 AX775931 CAE11665 AX775933 CAE11666 BC001000 AAH01000 BC037268 AAH37268 BP367689 CA447784 CB994021 CD522081 DQ890890 ABM81816 DQ894045 ABM84971 M55284 AAA60100 S74620 AAB32724 XM_011536954 XP_011535256 XM_011536955 XP_011535257 XM_011536956 XP_011535258 XM_011536957 XP_011535259 NM_006255 NP_006246
Function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epith
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Most abundant in lung, less in heart and skin. {ECO:0000269|PubMed:1986216}.
Top Pathways Tight junction, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels

PKC η (C-15) - sc-215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PKC η (C-15): sc-215. Western blot analysis of PKC η expression in rat (A) and mouse (B) lung tissue extracts.

PKC η (31) - sc-136036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PKC η (31): sc-136036. Western blot analysis of PKC η expression in WI 38 whole cell lysate.

Anti-PKC eta (phospho T655) antibody - ab5798 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Peptide Competition and Phosphatase Treatment Lysates prepared from Jurkat cells stimulated with PMA were resolved by SDS-PAGE on a 10% polyacrylamide gel and transferred to PVDF. Membranes were either left untreated (1-9) or treated with lambda phosphatase (10), blocked with a 5% BSA-TBST buffer overnight at 4°C, and incubated with 0.50 µg/mL ab5798 antibody for two hours at room temperature in a 3% BSA-TBST buffer, following prior incubation with: no peptide (1, 10), the non phosphopeptide corresponding to the immunogen (2), a generic phosphothreonine containing peptide (3), the phosphopeptide immunogen (4), or, the phosphopeptide corresponding to the immunogen from other PKC isoforms (5-9). After washing, membranes were incubated with goat (ab’)2 anti-rabbit IgG HRP-conjugate and bands were detected using the Pierce SuperSignalTM method. The data show that the peptide corresponding to PKC eta [pT655] blocks the antibody signal. The antibody signal was not blocked by the peptides cor

Anti-PKC eta antibody - ab4135 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PKC eta antibody - C-terminal - ab186065 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKC eta antibody - C-terminal (ab186065) at 0.1 µg/mlLane 1 : HeLa whole cell lysateLane 2 : 293T whole cell lysateLane 3 : Jurkat whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL techniqueExposure time : 3 minutes

Anti-PRKCH / PKC-Eta Antibody (phospho-Thr555/Thr563) - LS-C17469 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (aa672-683) - LS-C26203 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (phospho-Thr655) - LS-C26205 from LifeSpan Bioscience

Prices $495.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody - LS-C38549 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (phospho-Thr655) - LS-C91505 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody - LS-C91507 from LifeSpan Bioscience

Prices $295.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (aa580-737, clone 11n161) - LS-C184875 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 11n161

Anti-PRKCH / PKC-Eta Antibody (aa35-84) - LS-C135396 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRKCH / PKC-Eta antibody LS-C135396 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-PRKCH / PKC-Eta Antibody (aa313-341, AP) - LS-C267133 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (aa517-566) - LS-C135397 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PRKCH / PKC-Eta antibody LS-C135397 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-PRKCH / PKC-Eta Antibody (aa313-341, APC) - LS-C267134 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (aa313-341, Biotin) - LS-C267136 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (aa313-341, FITC) - LS-C267137 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (aa313-341, Azide-free, HRP) - LS-C267138 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody - LS-C202977 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant protein of PKC isoforms using Rabbit Anti-PKC eta Polyclonal Antibody,. demonstrating the isoform-specificity of this antibody.

Anti-PRKCH / PKC-Eta Antibody - LS-C136930 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (aa313-341, PE) - LS-C267140 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (N-Terminus, AP) - LS-C281432 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (N-Terminus, APC) - LS-C281434 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKCH / PKC-Eta Antibody (N-Terminus, Biotin) - LS-C281435 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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