PRKCH

Gene Symbol	PRKCH
Entrez Gene	5583
Alt Symbol	PKC-L, PKCL, PRKCL, nPKC-eta
Species	Human
Gene Type	protein-coding
Description	protein kinase C, eta
Other Description	protein kinase C eta type
Swissprots	P24723 Q8NE03 Q16246 B4DJN5
Accessions	AAD12779 CAH05605 CBX47631 EAW80800 EAW80801 EAW80802 P24723 AB451313 BAG70127 AK093241 AK290183 BAF82872 AK296158 BAG58897 AK300864 BAG62513 AW008462 AX775931 CAE11665 AX775933 CAE11666 BC001000 AAH01000 BC037268 AAH37268 BP367689 CA447784 CB994021 CD522081 DQ890890 ABM81816 DQ894045 ABM84971 M55284 AAA60100 S74620 AAB32724 XM_011536954 XP_011535256 XM_011536955 XP_011535257 XM_011536956 XP_011535258 XM_011536957 XP_011535259 NM_006255 NP_006246
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epith
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Most abundant in lung, less in heart and skin. {ECO:0000269|PubMed:1986216}.
Top Pathways	Tight junction, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKC eta full length protein - ab60849 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PKC eta full length protein - ab159202 from Abcam Category Protein Source Wheat germ Species Human

Human PKC eta protein fragment - ab159203 from Abcam Category Protein Source Wheat germ Species Human

PRKCH / PKC-Eta Antibody Blocking Peptide - LS-E3452 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCH / PKC-Eta Antibody Blocking Peptide - LS-E20628 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCH / PKC-Eta Antibody Blocking Peptide - LS-E20629 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCH / PKC-Eta Antibody Blocking Peptide - LS-E8610 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PKC eta Protein - H00005583-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PKC eta Protein - H00005583-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

PKC eta Recombinant Protein - P4215 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

PKC eta Protein - NBP1-99884 from Novus Biologicals Category Protein Prices $309.00 Sizes 5 µg

PKC eta Peptide - P2107 from Novus Biologicals Category Peptide Species Human

PKC-eta-Antibody-N-term-Blocking-Peptide - BP7020a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PKC eta (Active) recombinant protein - GTX65214 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

PRKCH Blocking Peptide - 33R-4466 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Prkch Blocking Peptide - 33R-9219 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Protein Kinase C Eta Protein - abx068752 from Abbexa Category Protein Source E.coli Species Human

PRKCH - H00005583-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKCH - H00005583-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKCH - H00005583-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

PRKCH - H00005583-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

PRKCH - H00005583-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

PRKCH - P4215 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

Protein Kinase C Eta (PKCh), Human - 20-6475 from ARP American Research Products Category Protein Prices $527.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human Protein Kinase C, Eta, GST-tagged, Active - PRKCH-403H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

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